PMID- 6861787
OWN - NLM
STAT- MEDLINE
DCOM- 19830811
LR  - 20190825
IS  - 0340-6997 (Print)
IS  - 0340-6997 (Linking)
VI  - 8
IP  - 4
DP  - 1983
TI  - Comparative quality control of 99mTc-Pyrophosphate and 99mTc-diphosphonate 
      radiopharmaceuticals.
PG  - 179-82
AB  - The results of analysis of 99mTc-Pyrophosphate (99mPyP), taken as a 
      representative of the group of compounds having an organic P-O-P bond, and of the 
      three diphosphonate compounds: methylene diphosphonate (MDP), 2,3-dicarboxy 
      propane diphosphonate (DPD) and ethane-1-hydroxy-1, 1-diphosphonate (EHDP), which 
      differ in their chemical structure, are shown. Also, some physicochemical 
      parameters such as chloroform-water apparent partition coefficient, the osmotic 
      pressure and pH values in final preparations were studied. The radiochemical 
      purity of these radiopharmaceuticals was determined by the two methods: Sephadex 
      chromatography for separation of 99mTc-hydrolysate and TLC on silica gel with 85% 
      methanol for the determination of free 99mTcO-4. The yield of labelling for both 
      methods was over 90%. Also, pharmacokinetic parameters such as binding to the 
      plasma proteins and to erythrocytes were determined. 99mTc-PyP binding to plasma 
      proteins was higher than the binding of diphosphonate compounds. The quantitative 
      distribution of preparations was determined in experimental animals.
FAU - Jovanovic, V
AU  - Jovanovic V
FAU - Maksin, T
AU  - Maksin T
FAU - Rastovac, M
AU  - Rastovac M
FAU - Bzenic, J
AU  - Bzenic J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Eur J Nucl Med
JT  - European journal of nuclear medicine
JID - 7606882
RN  - 0 (Diphosphonates)
RN  - 0 (Polyphosphates)
RN  - 0 (Technetium Compounds)
RN  - 0 (Tin Polyphosphates)
RN  - 54627-10-0 (technetium Tc 99m stannous pyrophosphate)
RN  - 5L76I61H2B (Technetium Tc 99m Pyrophosphate)
RN  - 7440-26-8 (Technetium)
RN  - 8V3FGC4J77 (technetium Tc 99m diphosphonate)
SB  - IM
MH  - Animals
MH  - Diphosphonates/metabolism/*standards
MH  - Kinetics
MH  - Polyphosphates/*standards
MH  - Protein Binding
MH  - Quality Control
MH  - Rats
MH  - Technetium/metabolism/*standards
MH  - *Technetium Compounds
MH  - *Technetium Tc 99m Pyrophosphate
MH  - Tin Polyphosphates/metabolism/*standards
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
AID - 10.1007/BF00252891 [doi]
PST - ppublish
SO  - Eur J Nucl Med. 1983;8(4):179-82. doi: 10.1007/BF00252891.