PMID- 6863849
OWN - NLM
STAT- MEDLINE
DCOM- 19830826
LR  - 20181113
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 6
IP  - 2
DP  - 1983 Apr
TI  - Relationships between iodothyronine peripheral metabolism and ketone bodies 
      during hypocaloric dietary manipulations.
PG  - 81-9
AB  - Relationships between iodothyronine and metabolic substrate metabolism during 
      undernutrition were evaluated in four normal subjects who fasted for 48h (Group 
      I) and in four groups (II to V) of obese patients who underwent selective dietary 
      manipulations: 360 calories [carbohydrate (CHO) 40 g/day]; 800 calories 
      containing respectively 19 g/day - ketogenic - (K) and 112 g/day - non ketogenic 
      - (NK) of CHO; and a step-diet programme (during which total calories were 
      progressively reduced from 2500 to 500). Serum T3 levels decreased significantly 
      and constantly during fasting, 360 and 800 K studies, and transiently during the 
      800 NK diet. During the step-diet programme, a significant fall was found only 
      when 1250 K or less were given. Conversely, serum reverse T3 rose significantly 
      and constantly during 360 and 800 K diets, while a transient increase was found 
      during the 800 NK diet. During the step-diet programme reverse T3 rose only when 
      750 calories were given. Ketogenesis developed in all studies but one (800 NK), 
      and in the step-diet programme significantly below the 1000 calorie step. Other 
      substrate modifications in each study were also evaluated. Serum T3 levels showed 
      a significant correlation with ketone bodies (KB) in all the ketogenic studies, 
      while no correlation was found in non ketogenic study (800 NK). During the 
      step-diet programme ketone bodies and iodothyronine modifications appeared to be 
      related to the amount of calories. Based on these results, we suggest a 
      relationship between the dietary-induced modifications of iodothyronine 
      metabolism and the development of ketogenesis.
FAU - Pasquali, R
AU  - Pasquali R
FAU - Baraldi, G
AU  - Baraldi G
FAU - Biso, P
AU  - Biso P
FAU - Pasqui, F
AU  - Pasqui F
FAU - Mattioli, L
AU  - Mattioli L
FAU - Capelli, M
AU  - Capelli M
FAU - Calliva, R
AU  - Calliva R
FAU - Spoto, M
AU  - Spoto M
FAU - Melchionda, N
AU  - Melchionda N
FAU - Labo, G
AU  - Labo G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Acetoacetates)
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Hydroxybutyrates)
RN  - 0 (Ketone Bodies)
RN  - 0 (Lactates)
RN  - 0 (Triglycerides)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 4ZI204Y1MC (acetoacetic acid)
SB  - IM
MH  - Acetoacetates/blood
MH  - Adult
MH  - Blood Glucose/analysis
MH  - *Diet, Reducing
MH  - *Fasting
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Humans
MH  - Hydroxybutyrates/blood
MH  - Ketone Bodies/*blood
MH  - Lactates/blood
MH  - Lactic Acid
MH  - Male
MH  - Triglycerides/blood
MH  - Triiodothyronine/*blood
EDAT- 1983/04/01 00:00
MHDA- 1983/04/01 00:01
CRDT- 1983/04/01 00:00
PHST- 1983/04/01 00:00 [pubmed]
PHST- 1983/04/01 00:01 [medline]
PHST- 1983/04/01 00:00 [entrez]
AID - 10.1007/BF03350577 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 1983 Apr;6(2):81-9. doi: 10.1007/BF03350577.