PMID- 6864438
OWN - NLM
STAT- MEDLINE
DCOM- 19830826
LR  - 20190913
IS  - 0386-846X (Print)
IS  - 0386-846X (Linking)
VI  - 6
IP  - 2
DP  - 1983 Feb
TI  - Effect of N-formyl-L-methionyl-L-leucyl-L-phenylalanine and its analogues on 
      blood pressure.
PG  - 141-4
AB  - Effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP), the synthetic 
      chemotactic peptide, and its analogues on blood pressure were investigated in the 
      rabbit, rat, mouse, dog, cat and guinea pig. The administration of FMLP (5 
      micrograms/kg i.v.) induced the depressor effect in the rabbit but no effect was 
      observed in the other animal species. The only peptide which showed a similar 
      effect as FMLP was N-formyl-L-methionyl-L-methionyl-L-phenylalanine (FMMP) among 
      the peptides relating to FMLP. Tachyphylaxis was observed in the hypotensive 
      action induced by the two peptides.
FAU - Saito, H
AU  - Saito H
FAU - Matsuo, M
AU  - Matsuo M
FAU - Naminohira, S
AU  - Naminohira S
FAU - Sakai, T
AU  - Sakai T
FAU - Kitagawa, H
AU  - Kitagawa H
FAU - Hirata, A A
AU  - Hirata AA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - J Pharmacobiodyn
JT  - Journal of pharmacobio-dynamics
JID - 7901854
RN  - 0 (Oligopeptides)
RN  - 4289-98-9 (N-Formylmethionine)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - AE28F7PNPL (Methionine)
RN  - N9YNS0M02X (Acetylcholine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Cats
MH  - Dogs
MH  - Guinea Pigs
MH  - Male
MH  - Methionine/*analogs & derivatives
MH  - Mice
MH  - Mice, Inbred ICR
MH  - N-Formylmethionine/*analogs & derivatives/pharmacology
MH  - N-Formylmethionine Leucyl-Phenylalanine
MH  - Norepinephrine/pharmacology
MH  - Oligopeptides/*pharmacology
MH  - Rabbits
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Species Specificity
EDAT- 1983/02/01 00:00
MHDA- 1983/02/01 00:01
CRDT- 1983/02/01 00:00
PHST- 1983/02/01 00:00 [pubmed]
PHST- 1983/02/01 00:01 [medline]
PHST- 1983/02/01 00:00 [entrez]
AID - 10.1248/bpb1978.6.141 [doi]
PST - ppublish
SO  - J Pharmacobiodyn. 1983 Feb;6(2):141-4. doi: 10.1248/bpb1978.6.141.