PMID- 6865775
OWN - NLM
STAT- MEDLINE
DCOM- 19830826
LR  - 20220321
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 32
IP  - 8
DP  - 1983 Aug
TI  - The human metabolic response to chronic ketosis without caloric restriction: 
      physical and biochemical adaptation.
PG  - 757-68
AB  - To study the metabolic effects of ketosis without weight loss, nine lean men were 
      fed a eucaloric balanced diet (EBD) for one week providing 35-50 kcal/kg/d, 1.75 
      g of protein per kilogram per day and the remaining kilocalories as two-thirds 
      carbohydrate (CHO) and one-third fat. This was followed by four weeks of a 
      eucaloric ketogenic diet (EKD)--isocaloric and isonitrogenous with the EBD but 
      providing less than 20 g CHO daily. Both diets were appropriately supplemented 
      with minerals and vitamins. Weight and whole-body potassium estimated by 
      potassium-40 counting (40K) did not vary significantly during the five-week 
      study. Nitrogen balance (N-Bal) was regained after one week of the EKD. The 
      fasting blood glucose remained lower during the EKD than during the control diet 
      (4.4 mmol/L at EBD, 4.1 mmol/L at EKD-4, P less than 0.01). The fasting 
      whole-body glucose oxidation rate determined by a 13C-glucose primed constant 
      infusion technique fell from 0.71 mg/kg/min during the control diet to 0.50 
      mg/kg/min (P less than 0.01) during the fourth week of the EKD. The mean serum 
      cholesterol level rose (from 159 to 208 mg/dL) during the EKD, while 
      triglycerides fell from 107 to 79 mg/dL. No disturbance of hepatic or renal 
      function was noted at EKD-4. These findings indicate that the ketotic state 
      induced by the EKD was well tolerated in lean subjects; nitrogen balance was 
      regained after brief adaptation, serum lipids were not pathologically elevated, 
      and blood glucose oxidation at rest was measurably reduced while the subjects 
      remained euglycemic.
FAU - Phinney, S D
AU  - Phinney SD
FAU - Bistrian, B R
AU  - Bistrian BR
FAU - Wolfe, R R
AU  - Wolfe RR
FAU - Blackburn, G L
AU  - Blackburn GL
LA  - eng
GR  - AM-26349/AM/NIADDK NIH HHS/United States
GR  - GM-22691/GM/NIGMS NIH HHS/United States
GR  - RR-88/RR/NCRR NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Acidosis/*blood
MH  - Adaptation, Physiological
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Composition
MH  - *Diet
MH  - *Energy Intake
MH  - Humans
MH  - Ketosis/*blood
MH  - Kidney Function Tests
MH  - Liver Function Tests
MH  - Male
MH  - Oxidation-Reduction
EDAT- 1983/08/01 00:00
MHDA- 1983/08/01 00:01
CRDT- 1983/08/01 00:00
PHST- 1983/08/01 00:00 [pubmed]
PHST- 1983/08/01 00:01 [medline]
PHST- 1983/08/01 00:00 [entrez]
AID - 0026-0495(83)90105-1 [pii]
AID - 10.1016/0026-0495(83)90105-1 [doi]
PST - ppublish
SO  - Metabolism. 1983 Aug;32(8):757-68. doi: 10.1016/0026-0495(83)90105-1.