PMID- 6870198
OWN - NLM
STAT- MEDLINE
DCOM- 19830826
LR  - 20131121
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 3
IP  - 3
DP  - 1983 May-Jun
TI  - The carcinogenic effect of intracolonic administration of 1,2-dimethylhydrazine 
      dihydrochloride in mice.
PG  - 167-70
AB  - 1,2-Dimethylhydrazine dihydrochloride (1,2-DMH) was given to Swiss mice in 1 or 
      10 weekly intracolonic instillations of 60 and 40 micrograms/g body weight, 
      respectively. In mice that received a single treatment, the tumor incidences in 
      the lungs, blood vessels and subcutis were 34% (p less than 0.006), 8 and 25 in 
      females and 2, 20 and 0% in males, respectively. In mice treated repeatedly with 
      the carcinogen, the corresponding tumor incidences were 34% (p less than 0.006), 
      38% (p less than 0.000001) and 12% (p less than 0.03) in females and 34, 10 and 
      0% in males, respectively. In control mice the tumor incidences in lungs, blood 
      vessels and subcutis were 15, 8 and 2% in females and 22, 5 and 2% in males, 
      respectively. The induction of large intestinal cancer, which was the main 
      objective of this investigation, however, failed to materialize.
FAU - Toth, B
AU  - Toth B
FAU - Patil, K
AU  - Patil K
LA  - eng
GR  - N01-CPO5621/CP/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Carcinogens)
RN  - 0 (Dimethylhydrazines)
RN  - 0 (Methylhydrazines)
RN  - IX068S9745 (1,2-Dimethylhydrazine)
SB  - IM
MH  - 1,2-Dimethylhydrazine
MH  - Animals
MH  - *Carcinogens
MH  - Colon
MH  - Dimethylhydrazines/administration & dosage/*toxicity
MH  - Female
MH  - Intestinal Neoplasms/chemically induced
MH  - Lung Neoplasms/chemically induced
MH  - Male
MH  - Methylhydrazines/*toxicity
MH  - Mice
MH  - Neoplasms, Experimental/*chemically induced
MH  - Neoplasms, Vascular Tissue/chemically induced
MH  - Skin Neoplasms/chemically induced
EDAT- 1983/05/01 00:00
MHDA- 1983/05/01 00:01
CRDT- 1983/05/01 00:00
PHST- 1983/05/01 00:00 [pubmed]
PHST- 1983/05/01 00:01 [medline]
PHST- 1983/05/01 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1983 May-Jun;3(3):167-70.