PMID- 6871923
OWN - NLM
STAT- MEDLINE
DCOM- 19830923
LR  - 20131121
IS  - 0149-2918 (Print)
IS  - 0149-2918 (Linking)
VI  - 5
IP  - 4
DP  - 1983
TI  - Therapy of congestive heart failure with orally administered taurine.
PG  - 398-408
AB  - The clinical efficacy of 2 gm BID of oral taurine (2-aminoethane sulfonic acid) 
      was studied in 24 patients with congestive heart failure (CHF). We expressed the 
      severity of CHF by a score based on clinical signs and symptoms and on 
      roentgenographic data. The maximum possible score, corresponding to the worst 
      CHF, was 23 points. How much the 24 patients improved after receiving taurine for 
      four or eight weeks was estimated by the difference between their pretreatment 
      and posttreatment scores. In 19 of the 24 patients, taurine was effective. In the 
      group as a whole, mean (+/- SEM) scores fell significantly, from 7.3 +/- 0.6 
      before treatment to 4.4 +/- 0.5 after treatment. Thirteen of the 15 patients who 
      were designated as New York Heart Association (NYHA) functional class III or IV 
      before receiving taurine could be designated as class II after they completed the 
      study. This pilot study should prompt further investigation into the possible use 
      of taurine in the treatment of patients with CHF.
FAU - Azuma, J
AU  - Azuma J
FAU - Hasegawa, H
AU  - Hasegawa H
FAU - Sawamura, A
AU  - Sawamura A
FAU - Awata, N
AU  - Awata N
FAU - Ogura, K
AU  - Ogura K
FAU - Harada, H
AU  - Harada H
FAU - Yamamura, Y
AU  - Yamamura Y
FAU - Kishimoto, S
AU  - Kishimoto S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Ther
JT  - Clinical therapeutics
JID - 7706726
RN  - 1EQV5MLY3D (Taurine)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Female
MH  - Heart Failure/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardium/analysis
MH  - Oxygen Consumption/drug effects
MH  - Pilot Projects
MH  - Taurine/*administration & dosage/adverse 
      effects/analysis/pharmacology/therapeutic use
EDAT- 1983/01/01 00:00
MHDA- 1983/01/01 00:01
CRDT- 1983/01/01 00:00
PHST- 1983/01/01 00:00 [pubmed]
PHST- 1983/01/01 00:01 [medline]
PHST- 1983/01/01 00:00 [entrez]
PST - ppublish
SO  - Clin Ther. 1983;5(4):398-408.