PMID- 6872331
OWN - NLM
STAT- MEDLINE
DCOM- 19830923
LR  - 20190825
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 10
IP  - 2
DP  - 1983 Mar-Apr
TI  - Modification by GABA-ergic agents and clonidine of morphine-induced convulsions 
      and toxicity in rats.
PG  - 125-9
AB  - Intracerebroventricular (i.c.v.) administration of morphine produced 
      dose-dependent behavioural changes in rats, the highest dose producing violent 
      tonic convulsions. Naloxone (up to 10 mg/kg i.p., or 100 micrograms i.c.v.) 
      failed to reverse morphine-induced toxicity. The conventional anticonvulsant 
      drugs also failed to offer protection to morphine-induced seizures. GABA-ergic 
      substances, GABA, piracetam and diazepam, on the other hand, protected the 
      animals against morphine-induced convulsions and toxicity. Similarly, clonidine 
      pretreatment also had a protective action against morphine-induced convulsions.
FAU - Kulkarni, S K
AU  - Kulkarni SK
FAU - Nagrath, A
AU  - Nagrath A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Anticonvulsants)
RN  - 36B82AMQ7N (Naloxone)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 76I7G6D29C (Morphine)
RN  - MN3L5RMN02 (Clonidine)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/pharmacology
MH  - Behavior, Animal/drug effects
MH  - Clonidine/*pharmacology
MH  - Female
MH  - Injections, Intraventricular
MH  - Male
MH  - Morphine/*antagonists & inhibitors/toxicity
MH  - Naloxone/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Seizures/chemically induced/*prevention & control
MH  - gamma-Aminobutyric Acid/*physiology
EDAT- 1983/03/01 00:00
MHDA- 1983/03/01 00:01
CRDT- 1983/03/01 00:00
PHST- 1983/03/01 00:00 [pubmed]
PHST- 1983/03/01 00:01 [medline]
PHST- 1983/03/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1983.tb00178.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 1983 Mar-Apr;10(2):125-9. doi: 
      10.1111/j.1440-1681.1983.tb00178.x.