PMID- 6875642
OWN - NLM
STAT- MEDLINE
DCOM- 19830923
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 50
IP  - 1
DP  - 1983 Jul
TI  - Localization and characteristics of responses in cat medial preoptic region to 
      stimulation of fornix.
PG  - 125-35
AB  - Field potentials and units were recorded within the boundaries of the cat medial 
      preoptic area (MPO) following stimulation of the fornix. The position of the 
      recording electrode was marked by pressure injection of alcian blue dye. 
      Stimulation of the medial and lateral aspects of the ipsilateral fornix produced 
      a field consisting of four negative waves and a positive wave. The first and 
      second negative waves had a short latency and duration and appeared to be 
      produced by fornix axons in the MPO. The third negative wave had a longer 
      duration and appeared to be generated by the monosynaptic activation of units in 
      the MPO. The fourth negative wave had a long latency and very long duration and 
      appeared to be generated by polysynaptic activation of neurons in the MPO. The 
      positive wave was associated with inhibition of MPO neurons as a result of fornix 
      excitation of inhibitory interneurons. Responses from nerve fibers in the MPO had 
      latencies corresponding to peaks of the first and second peaks of the evoked 
      potential. Monosynaptically evoked responses to ipsilateral fornix stimulation 
      were recorded all over the dorsal two-thirds of the MPO. Units driven from the 
      medial fornix lay in the periventricular nucleus. Units driven from the lateral 
      fornix lay in the medial preoptic nucleus. Units driven from both medial and 
      lateral fornix lay between units driven by the medial fornix medially and the 
      lateral fornix laterally. Units driven polysynaptically from the ipsilateral 
      fornix lay in the medial preoptic nucleus. About one-quarter of such units were 
      also excited by stimulation of the contralateral fornix. Spontaneously 
      discharging units were recorded all over the MPO. The geometric mean frequency 
      was 2.1 +/- 1.7-2.8 Hz; n = 35. Fornix stimulation inhibited spontaneous units in 
      the medial preoptic nucleus for 50-200 ms. Usually inhibition was evoked by 
      lateral fornix stimulation or by medial or lateral fornix stimulation. 
      Spontaneously discharging units in the periventricular nuclei were not inhibited 
      by fornix stimulation. The position of fornix-excited units suggests they might 
      be temperature sensitive and in female animals, play a role in controlling 
      ovulation.
FAU - Hubbard, J I
AU  - Hubbard JI
FAU - Mills, R G
AU  - Mills RG
FAU - Sirett, N E
AU  - Sirett NE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Cats
MH  - Cerebral Cortex/*physiology
MH  - Dominance, Cerebral/physiology
MH  - Electric Stimulation
MH  - Evoked Potentials
MH  - Hippocampus/*physiology
MH  - Hypothalamus/*physiology
MH  - Hypothalamus, Posterior/*physiology
MH  - Neural Pathways/physiology
MH  - Neurons/physiology
MH  - Preoptic Area/*physiology
MH  - Septal Nuclei/*physiology
MH  - Synapses/physiology
EDAT- 1983/07/01 00:00
MHDA- 1983/07/01 00:01
CRDT- 1983/07/01 00:00
PHST- 1983/07/01 00:00 [pubmed]
PHST- 1983/07/01 00:01 [medline]
PHST- 1983/07/01 00:00 [entrez]
AID - 10.1152/jn.1983.50.1.125 [doi]
PST - ppublish
SO  - J Neurophysiol. 1983 Jul;50(1):125-35. doi: 10.1152/jn.1983.50.1.125.