PMID- 6883574
OWN - NLM
STAT- MEDLINE
DCOM- 19831028
LR  - 20190825
IS  - 0009-2797 (Print)
IS  - 0009-2797 (Linking)
VI  - 45
IP  - 3
DP  - 1983 Aug 1
TI  - Metabolism of parenterally administered zinc and cadmium in livers of newborn 
      rats.
PG  - 327-39
AB  - The interaction of injected zinc and cadmium with metallothionein was 
      investigated in newborn rats. Tissues of 5-day-old rats were removed 24 h after a 
      single injection (Sc) of saline or zinc (20 mg/kg, body wt.) or cadmium (1 mg/kg, 
      body wt.) with 2.5 muCi of 65Zn or 109Cd or 5 muCi of [35S]-cysteine. Injection 
      of zinc resulted in a 75% increase in the hepatic zinc concentration with a 
      concomitant elevation of metallothionein (P less than 0.001), zinc in 
      metallothionein increased by 45% (P less than 0.05); [35S]cysteine incorporation 
      indicated the induced synthesis of metallothionein. Injection of cadmium did not 
      alter either metallothionein or zinc levels in liver, but cadmium in cytosol was 
      preferentially bound to metallothionein. Neither treatment altered hepatic copper 
      metabolism and copper in metallothionein, nor renal zinc and metallothionein 
      levels. These data indicate that zinc injection can elevate hepatic zinc levels 
      and induce metallothionein synthesis in newborn rats despite high basal levels; 
      cadmium injection does not induce metallothionein synthesis, though cadmium is 
      avidly sequestered by pre-existing metallothionein. The differences in the 
      induction of metallothionein by these divalent cations can be explained by the 
      differences in their binding affinities for thiol groups in intracellular 
      metallothionein.
FAU - Panemangalore, M
AU  - Panemangalore M
FAU - Cherian, M G
AU  - Cherian MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Metalloproteins)
RN  - 00BH33GNGH (Cadmium)
RN  - 9038-94-2 (Metallothionein)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cadmium/administration & dosage/*metabolism
MH  - Female
MH  - Injections, Subcutaneous
MH  - Kidney/metabolism
MH  - Liver/*metabolism
MH  - Metalloproteins/*metabolism
MH  - Metallothionein/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Subcellular Fractions/metabolism
MH  - Zinc/administration & dosage/*metabolism
EDAT- 1983/08/01 00:00
MHDA- 1983/08/01 00:01
CRDT- 1983/08/01 00:00
PHST- 1983/08/01 00:00 [pubmed]
PHST- 1983/08/01 00:01 [medline]
PHST- 1983/08/01 00:00 [entrez]
AID - 0009-2797(83)90079-0 [pii]
AID - 10.1016/0009-2797(83)90079-0 [doi]
PST - ppublish
SO  - Chem Biol Interact. 1983 Aug 1;45(3):327-39. doi: 10.1016/0009-2797(83)90079-0.