PMID- 6891551
OWN - NLM
STAT- MEDLINE
DCOM- 19830324
LR  - 20190812
IS  - 0001-6322 (Print)
IS  - 0001-6322 (Linking)
VI  - 58
IP  - 3
DP  - 1982
TI  - Plasminogen activators in rat neural tissues during development and in Wallerian 
      degeneration.
PG  - 224-8
AB  - The fibrinolytic activity of blood is caused by plasminogen activators (PA) 
      converting plasminogen to plasmin, the active fibrinolytic protease. PA activity 
      in rat neural tissues was studied by Todd's fibrin slide technique. Cryostat 
      sections overlayed with a film of plasminogen and fibrin were incubated for 60-90 
      min. PA activity was related to the size of the zone of fibrinolysis surrounding 
      the sections. No lysis occurred with fibrin alone. In rats perfused with saline 
      prior to decapitation the size of the zone of lysis was approximately the same as 
      in non-perfused animals. PA activity was compared in the following tissues: adult 
      (2-3 month) cerebellum and 6-14-day postnatal cerebellum; normal sciatic nerve 
      and transected sciatic nerve 1-9 weeks after operation (in these experiments the 
      sciatic nerve was crushed on the left side, on the right side it was transected 
      and the stumps were tightly ligated to prevent regeneration); normal optic nerves 
      and optic nerves undergoing Wallerian degeneration 1-2 weeks after enucleation of 
      the eye. As compared to normal cerebellum PA activity was increased in 6-14-day 
      cerebellum. PA activity was also markedly increased in both crushed and ligated 
      sciatic nerves 1-4 weeks after operation while no differences were observed 
      between normal sciatic nerves and sciatic nerves 9 weeks after ligation. The zone 
      of fibrinolysis surrounding normal optic nerves and the optic nerves of blinded 
      rats was approximately the same. It is proposed that the fibrinolytic system may 
      be relevant to the problem of CNS regeneration.
FAU - Bignami, A
AU  - Bignami A
FAU - Cella, G
AU  - Cella G
FAU - Chi, N H
AU  - Chi NH
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - Acta Neuropathol
JT  - Acta neuropathologica
JID - 0412041
RN  - EC 3.4.21.- (Plasminogen Activators)
SB  - IM
MH  - Animals
MH  - Cerebellum/analysis
MH  - *Nerve Degeneration
MH  - Nerve Tissue/*analysis
MH  - Optic Nerve/analysis
MH  - Plasminogen Activators/*analysis
MH  - Rats
MH  - Sciatic Nerve/analysis
MH  - *Wallerian Degeneration
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1007/BF00690805 [doi]
PST - ppublish
SO  - Acta Neuropathol. 1982;58(3):224-8. doi: 10.1007/BF00690805.