PMID- 69150
OWN - NLM
STAT- MEDLINE
DCOM- 19770902
LR  - 20190610
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 2
IP  - 8028
DP  - 1977 Jul 9
TI  - Diagnostic importance of changes in circulating concentrations of immunoreactive 
      trypsin.
PG  - 66-8
AB  - A specific and sensitive radioimmunoassay (R.I.A.) has been developed which makes 
      possible the determination of serum or plasma trypsin concentrations despite the 
      presence of trypsin inhibitors, which have invaldiated previously available 
      enzymatic techniques. The assay was most precise at about 300 microng trypsin 
      standard Ag5 per litre of serum, a value comparable with the mean in 76 healthy 
      volunteers (273 microng/1) and in 20 hospital patients with non-pancreatic 
      disease (266 microng/1). Markedly raised concentrations (970-6500 microng/1) were 
      found in all 14 patients with acute pancreatitis and in 8 patients with chronic 
      renal failure (580-1360 microng/1). Abnormal concentrations were found in 11 of 
      16 patients (69%) with pancreatic cancer (8 high, 3 low) and in 15 of 23 patients 
      (65%) with chronic pancreatitis (3 high, 12 low). Patients with jaundice had 
      normal or marginally lower than normal concentrations unless pancreatic disease 
      or common-duct gallstones were present.
FAU - Elias, E
AU  - Elias E
FAU - Redshaw, M
AU  - Redshaw M
FAU - Wood, T
AU  - Wood T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Antigens)
RN  - EC 3.4.21.4 (Trypsin)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Antigens
MH  - Chronic Disease
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Gallstones/enzymology
MH  - Humans
MH  - Jaundice/enzymology
MH  - Kidney Failure, Chronic/enzymology
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/enzymology
MH  - Pancreatitis/enzymology
MH  - Radioimmunoassay/methods
MH  - Trypsin/*blood
EDAT- 1977/07/09 00:00
MHDA- 1977/07/09 00:01
CRDT- 1977/07/09 00:00
PHST- 1977/07/09 00:00 [pubmed]
PHST- 1977/07/09 00:01 [medline]
PHST- 1977/07/09 00:00 [entrez]
AID - S0140-6736(77)90066-6 [pii]
AID - 10.1016/s0140-6736(77)90066-6 [doi]
PST - ppublish
SO  - Lancet. 1977 Jul 9;2(8028):66-8. doi: 10.1016/s0140-6736(77)90066-6.