PMID- 6927545
OWN - NLM
STAT- MEDLINE
DCOM- 19860501
LR  - 20131121
IS  - 0379-8305 (Print)
IS  - 0379-8305 (Linking)
VI  - 1
IP  - 2-3
DP  - 1980
TI  - Tissue distribution of morphine in the newborns of addicted monkeys and humans. 
      Clinical implications.
PG  - 163-70
AB  - The distribution of morphine in various tissues of 6 addicted monkey fetuses and 
      in 2 infants of drug-dependent mothers (IDDM) show that significant 
      concentrations of the drug are in the gastrointestines (tissue plus content), 
      liver, cerebellum, lungs, heart, spleen and thymus. The high concentration of 
      morphine in the gastrointestinal tract may be secondary to the excretion of the 
      drug through the bile or by the repeated swallowing by the fetus of amniotic 
      fluid which contains morphine (1.9 +/- 1.0 micrograms/dl). Meconium, taken from 2 
      IDDMs show a significant concentration of morphine for up to 2-3 days after 
      birth. Thus, meconium is a useful material to analyze postnatally for the 
      diagnosis of neonatal narcotic addiction.
FAU - Ostrea, E M Jr
AU  - Ostrea EM Jr
FAU - Lynn, S M
AU  - Lynn SM
FAU - Wayne, R N
AU  - Wayne RN
FAU - Stryker, J C
AU  - Stryker JC
LA  - eng
GR  - 1H81DAO1855-01/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Dev Pharmacol Ther
JT  - Developmental pharmacology and therapeutics
JID - 8003947
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Digestive System/metabolism
MH  - Female
MH  - Fetus/*metabolism
MH  - Humans
MH  - Infant, Newborn
MH  - Macaca mulatta
MH  - Meconium/metabolism
MH  - Morphine/*metabolism
MH  - Morphine Dependence/*metabolism
MH  - Pregnancy
MH  - Tissue Distribution
EDAT- 1980/01/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1980/01/01 00:00
PHST- 1980/01/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1980/01/01 00:00 [entrez]
PST - ppublish
SO  - Dev Pharmacol Ther. 1980;1(2-3):163-70.