PMID- 693562
OWN - NLM
STAT- MEDLINE
DCOM- 19781202
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 8
IP  - 6
DP  - 1978 Jun
TI  - Tetrahydrocannabinol and acetylcholinesterase.
PG  - 763-5
AB  - Recent evidence suggests that the psychoactive effect of 
      delta-9-tetrahydrocannabinol (delta9-THC), the major psychoactive constituent of 
      marihuana, may be mediated through an alteration of cholinergic 
      neurotransmission. One possible mechanism by which delta9-THC could have its 
      effect is by affecting acetylcholinesterase (AChE) and there is evidence that has 
      suggested that this may be an important mechanism. The results reported in the 
      present study have shown that there is no physiologically important interaction 
      between AChE and delta9-THC or its metabolites that could explain its 
      psychoactive effects or the profound clinical depression observed when human 
      marihuana users are administered the cholinesterase inhibitor physostigmine.
FAU - Moss, D E
AU  - Moss DE
FAU - Peck, P L
AU  - Peck PL
FAU - Salome, R
AU  - Salome R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Cholinesterase Inhibitors)
RN  - 7J8897W37S (Dronabinol)
RN  - 9U1VM840SP (Physostigmine)
SB  - IM
MH  - Animals
MH  - Brain/enzymology
MH  - *Cholinesterase Inhibitors
MH  - Dronabinol/*pharmacology
MH  - Physostigmine/pharmacology
MH  - Rats
EDAT- 1978/06/01 00:00
MHDA- 1978/06/01 00:01
CRDT- 1978/06/01 00:00
PHST- 1978/06/01 00:00 [pubmed]
PHST- 1978/06/01 00:01 [medline]
PHST- 1978/06/01 00:00 [entrez]
AID - 0091-3057(78)90280-0 [pii]
AID - 10.1016/0091-3057(78)90280-0 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1978 Jun;8(6):763-5. doi: 10.1016/0091-3057(78)90280-0.