PMID- 693918
OWN - NLM
STAT- MEDLINE
DCOM- 19781202
LR  - 20190823
IS  - 0090-6980 (Print)
IS  - 0090-6980 (Linking)
VI  - 15
IP  - 6
DP  - 1978 Jun
TI  - Effects of intracerebroventricular administration of PGE1, E2 and F2alpha on 
      electrically induced convulsions in mice.
PG  - 925-42
AB  - Intracerebroventricular administration of prostaglandins E1 or E2 was shown to 
      block, while PGF2alpha increased the incidence of tonic convulsion due to 
      electroshock in mice. The Prostaglandins were administered 
      intracerebroventicularly (i.c.v.) to conscious mice by a modification of Haley 
      and McCormick's method (1) prior to a transcorneal maximal electroshock (MES) or 
      a transcorneal supra-maximal electroshock (SMES). PGE1 and PGE2 i.c.v. blocked 
      the tonic hindlimb extension (THE) and protected the animals from death induced 
      by MES with ED50's for PGE1 and PGE2 for inhibition of the THE of 6.6 (4.3--12.0) 
      microgram/mouse i.c.v. and 13.3 (8.9--22.4) microgram/mouse i.c.v. respectively. 
      When PGE2 was administered intraperitoneally (i.p.) in doses as high as 4.0 mg/kg 
      it did not block the THE. However, the duration of the THE as well as the 
      mortality were reduced by doses of 0.5--4.0 mg/kg PGE2 i.p.. Both PGE1 and PGE2 
      were shown to cause a dose related significant (p less than .001) decrease in the 
      duration of the THE with SMES in doses of 1--10 microgram/mouse i.c.v. for PGE1 
      and 2--40 microgram/mouse i.c.v. for PGE2. PGF2alpha, administered i.c.v. prior 
      to a transcorneal electroshock equivalent to a current at the ED1 level, 
      increased the incidence of the THE as well as the mortality in doses of 20--50 
      microgram/mouse.
FAU - Rosenkranz, R P
AU  - Rosenkranz RP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prostaglandins
JT  - Prostaglandins
JID - 0320271
RN  - 0 (Anticonvulsants)
RN  - 0 (Prostaglandins E)
RN  - 0 (Prostaglandins F)
SB  - IM
MH  - Animals
MH  - *Anticonvulsants
MH  - Brain/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Evaluation, Preclinical
MH  - Electroshock
MH  - Injections, Intraventricular
MH  - Lethal Dose 50
MH  - Male
MH  - Mice
MH  - Prostaglandins E/administration & dosage/*therapeutic use
MH  - Prostaglandins F/administration & dosage/*pharmacology
EDAT- 1978/06/01 00:00
MHDA- 1978/06/01 00:01
CRDT- 1978/06/01 00:00
PHST- 1978/06/01 00:00 [pubmed]
PHST- 1978/06/01 00:01 [medline]
PHST- 1978/06/01 00:00 [entrez]
AID - 0090-6980(78)90036-9 [pii]
AID - 10.1016/0090-6980(78)90036-9 [doi]
PST - ppublish
SO  - Prostaglandins. 1978 Jun;15(6):925-42. doi: 10.1016/0090-6980(78)90036-9.