PMID- 6942668
OWN - NLM
STAT- MEDLINE
DCOM- 19810922
LR  - 20190619
IS  - 0003-4819 (Print)
IS  - 0003-4819 (Linking)
VI  - 95
IP  - 2
DP  - 1981 Aug
TI  - Gold-induced thrombocytopenia. A clinical and immunogenetic study of twenty-three 
      patients.
PG  - 178-81
AB  - Thrombocytopenia developed in 23 patients with rheumatoid arthritis treated with 
      gold salts over 25 years. All patients recovered, and there were no episodes of 
      life-threatening hemorrhage; four patients eventually needed splenectomy. The 
      clinical presentation of gold-induced thrombocytopenia and its treatment and 
      outcome are reviewed. Because gold-induced thrombocytopenia is believed to have 
      an immunologic basis, we sought an association between this complication and 
      antigens of the human leukocyte antigen (HLA) region. The most significant 
      finding was the association of the HLA-DR3 alloantigen in 12 of 15 of these 
      patients compared with 26 of 84 in a control population (x2 12.9, p less than 
      0.001). This study provides further evidence that gold-induced thrombocytopenia 
      is immunologically mediated and that genes of the major histocompatibility 
      complex are involved.
FAU - Coblyn, J S
AU  - Coblyn JS
FAU - Weinblatt, M
AU  - Weinblatt M
FAU - Holdsworth, D
AU  - Holdsworth D
FAU - Glass, D
AU  - Glass D
LA  - eng
GR  - AM00449/AM/NIADDK NIH HHS/United States
GR  - AM05577/AM/NIADDK NIH HHS/United States
GR  - AM11414/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 7440-57-5 (Gold)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/drug therapy
MH  - Female
MH  - Gold/*adverse effects
MH  - Histocompatibility Antigens Class II/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prednisone/therapeutic use
MH  - Thrombocytopenia/*chemically induced/drug therapy/immunology
EDAT- 1981/08/01 00:00
MHDA- 1981/08/01 00:01
CRDT- 1981/08/01 00:00
PHST- 1981/08/01 00:00 [pubmed]
PHST- 1981/08/01 00:01 [medline]
PHST- 1981/08/01 00:00 [entrez]
AID - 10.7326/0003-4819-95-2-178 [doi]
PST - ppublish
SO  - Ann Intern Med. 1981 Aug;95(2):178-81. doi: 10.7326/0003-4819-95-2-178.