PMID- 6950201
OWN - NLM
STAT- MEDLINE
DCOM- 19820521
LR  - 20190821
IS  - 0385-5600 (Print)
IS  - 0385-5600 (Linking)
VI  - 25
IP  - 12
DP  - 1981
TI  - Cell surface expression of I-A products is required for contact sensitivity 
      induction by trinitrophenyl-coupled epidermal cells.
PG  - 1335-44
AB  - Trinitrophenyl (TNP)-couple epidermal cells (EC) injected subcutaneously (s.c.) 
      were more capable of inducing contact sensitivity (CS) to 2, 4, 
      6-trinitro-1-chlorobenzene (TNCB) than similarly substituted spleen cells 
      (TNP-SC). Furthermore, the intravenous (i.v.) or intraperitoneal (I.P) injection 
      of TNP-EC also induced CS response, whereas the i.v. or i.p. injection of TNP-SC 
      failed to induce them. Treatment of mice with cyclophosphamide (Cy; 50 mg/kg) or 
      anti- I-J serum allowed animals injected with TNP-SC i.v. to develop significant 
      CS responses, suggesting that Cy-sensitive and I-J positive regulatory cells were 
      involved in the induction of unresponsiveness by the I.V. injection of TNP-SC. 
      Mapping studies o the major histocompatibility gene complex (MHC) region 
      demonstrated that identity at the I-A subregion alone between EC donor and 
      recipient mice was sufficient for the induction of CS by TNP-EC given i.v. 
      Blocking experiments using antisera in the absence of complement indicated that 
      I-A subregion-encoded antigens on the surface of TNP-EC apparently are involved 
      in the induction of CS, and are not simply phenotypic markers on the surface of 
      accessory cells.
FAU - Ikezawa, Z
AU  - Ikezawa Z
FAU - Sato, M
AU  - Sato M
FAU - Nagai, R
AU  - Nagai R
FAU - Okuda, K
AU  - Okuda K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Nitrobenzenes)
RN  - 0 (Trinitrobenzenes)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Animals
MH  - Antilymphocyte Serum/pharmacology
MH  - Cyclophosphamide/pharmacology
MH  - Dermatitis, Contact/*immunology
MH  - Histocompatibility Antigens Class II/genetics/*immunology
MH  - Injections, Intraperitoneal
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C/genetics
MH  - Mice, Inbred C3H/genetics
MH  - Mice, Inbred C57BL/genetics
MH  - Nitrobenzenes/*immunology
MH  - Phenotype
MH  - Skin/immunology
MH  - Spleen/immunology
MH  - Trinitrobenzenes/*immunology
EDAT- 1981/01/01 00:00
MHDA- 1981/01/01 00:01
CRDT- 1981/01/01 00:00
PHST- 1981/01/01 00:00 [pubmed]
PHST- 1981/01/01 00:01 [medline]
PHST- 1981/01/01 00:00 [entrez]
AID - 10.1111/j.1348-0421.1981.tb00142.x [doi]
PST - ppublish
SO  - Microbiol Immunol. 1981;25(12):1335-44. doi: 10.1111/j.1348-0421.1981.tb00142.x.