PMID- 6950686
OWN - NLM
STAT- MEDLINE
DCOM- 19820512
LR  - 20071115
IS  - 0091-7370 (Print)
IS  - 0091-7370 (Linking)
VI  - 12
IP  - 1
DP  - 1982 Jan-Feb
TI  - The major histocompatibility complex.
PG  - 16-22
AB  - The major histocompatibility complex on the sixth chromosome controls expression 
      of a complex series of cell surface antigens which comprise the human leukocyte 
      antigen (HLA) system. These markers, beyond their importance in human organ 
      transplantation, have been demonstrated to occur with an increased prevalence in 
      certain disease states. The group of conditions showing the closest association 
      with specific HLA antigens are the "spondyloarthropathies." These include 
      ankylosing spondylitis (AS), Reiter's syndrome (RS), psoriatic arthritis (PsA), 
      and the arthritis of inflammatory bowel disease (AIBD). Clinical and radiographic 
      studies were made of 310 unrelated caucasoid patients with seronegative 
      arthritis. HLA-A, B, C, and DR typing were performed using the microdroplet 
      lymphocyte cytotoxicity test. Statistically increased prevalences of A26, B27, 
      and Bw38 were observed, while B27 was associated with spinal involvement 
      regardless of diagnosis (90 percent in AS p less than 0.0001). Experiments found 
      A26 (23 percent p less than 0.001) and Bw38 (38 percent p less than 0.0001) in 
      patients with PsA. Spondyloarthritis patients with spinal involvement who lacked 
      B27 frequently had B7. The HLA DR typing for seven specificities was carried out 
      in 196 patients. It was found that DRw4 (52 percent p less than 0.03) and DRw7 
      (39 percent p less than 0.04) were increased in the PsA patients. This study 
      further confirms the close association of HLA antigens and the 
      spondylarthropathies.
FAU - Vasey, F B
AU  - Vasey FB
FAU - Espinoza, L R
AU  - Espinoza LR
FAU - Bocanegra, T S
AU  - Bocanegra TS
FAU - Germain, B F
AU  - Germain BF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Arthritis/immunology
MH  - Arthritis, Reactive/immunology
MH  - HLA Antigens/immunology
MH  - HLA-B Antigens
MH  - HLA-C Antigens
MH  - HLA-DR Antigens
MH  - Histocompatibility Antigens Class II/immunology
MH  - Humans
MH  - Inflammation/immunology
MH  - Intestinal Diseases/immunology
MH  - *Major Histocompatibility Complex
MH  - Psoriasis/immunology
MH  - Spondylitis, Ankylosing/immunology
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Clin Lab Sci. 1982 Jan-Feb;12(1):16-22.