PMID- 6951003
OWN - NLM
STAT- MEDLINE
DCOM- 19820621
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 155
IP  - 5
DP  - 1982 May 1
TI  - HLA-Dw2: a genetic marker for human immune response to short ragweed pollen 
      allergen Ra5. I. Response resulting primarily from natural antigenic exposure.
PG  - 1439-51
AB  - Ultra-pure short ragweed pollen allergen Ra5 (5,000 mol wt) was used to 
      investigate the relationship between human leukocyte antigen (HLA) type and IgE 
      and IgG antibody (Ab) responses to Ra5 in two groups of Caucasian subjects, 
      totaling 447 people. Using highly sensitive radioimmunoassay procedures to 
      measure serum IgE and IgG Ab, qualitative responses to Ra5 in both groups were 
      found to be strongly associated with HLA-Dw2 (P less than 0.0001). For example, 
      95% of 38 people with IgE Ab vs. 22% of 139 ragweed-allergic persons having no 
      detectable IgE Ab to Ra5 were Dw2+. Quantitative log [IgE Ab] and log[IgG Ab] 
      responses to Ra5 were highly correlated with Dw2 (P = 10(-5) to 10(-14)) in four 
      separate multiple regression analyses, examining the relationship between HLA 
      type (and other variables) and Ab levels in the two study groups. Further studies 
      showed that the primary association of Ra5 response was with Dw2 rather than DR2 
      and that various combinations of A3, B7, and Dw2 were less strongly associated 
      than Dw2 alone.
FAU - Marsh, D G
AU  - Marsh DG
FAU - Hsu, S H
AU  - Hsu SH
FAU - Roebber, M
AU  - Roebber M
FAU - Ehrlich-Kautzky, E
AU  - Ehrlich-Kautzky E
FAU - Freidhoff, L R
AU  - Freidhoff LR
FAU - Meyers, D A
AU  - Meyers DA
FAU - Pollard, M K
AU  - Pollard MK
FAU - Bias, W B
AU  - Bias WB
LA  - eng
GR  - AI-13370/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Female
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Immunoglobulin E/biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Immunoglobulins/*biosynthesis
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Pollen/*immunology
MH  - Regression Analysis
MH  - Rhinitis, Allergic, Seasonal/genetics/immunology/therapy
MH  - Skin Tests
PMC - PMC2186667
EDAT- 1982/05/01 00:00
MHDA- 1982/05/01 00:01
PMCR- 1982/11/01
CRDT- 1982/05/01 00:00
PHST- 1982/05/01 00:00 [pubmed]
PHST- 1982/05/01 00:01 [medline]
PHST- 1982/05/01 00:00 [entrez]
PHST- 1982/11/01 00:00 [pmc-release]
AID - 82169264 [pii]
AID - 10.1084/jem.155.5.1439 [doi]
PST - ppublish
SO  - J Exp Med. 1982 May 1;155(5):1439-51. doi: 10.1084/jem.155.5.1439.