PMID- 6954254
OWN - NLM
STAT- MEDLINE
DCOM- 19820910
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 112
IP  - 7
DP  - 1982 Jul
TI  - Nutritional studies in the weanling rat with normophagic hypothalamic obesity.
PG  - 1441-55
AB  - Weanling male hypothalamic-obese Sprague-Dawley rats (VMNL) and sham-operated 
      controls (CON) fed stock diet for 2 weeks postoperatively ate similar amounts, 
      but VMNL laid down more fat and less body weight per calories. Three equicaloric 
      diets of different macronutrient (MN) content each were fed for 21 days. Diet 
      selection: VMNL selected more carbohydrate (CHO) diet and protein diet but 
      similar amounts of fat diet; total caloric intake was comparable. Percent diet 
      selection showed the identical pattern. MN intake: VMNL ingested more percent 
      CHO, less percent protein and similar percent fat as CON. Refeeding after 2-day 
      fast: both groups selected similar amounts of diets, but VMNL ingested less 
      protein. High protein diet along (9 days): both groups increased caloric intake 
      over previous regimens, weight gain and caloric intake were similar, but Lee 
      Index was higher in VMNL. Stock diet (32 days): VMNL showed normal body weight 
      gains but higher Lee Index despite hypophagia. They utilized calories similarly 
      for body weight gains but more poorly for fat deposition than CON. After death 
      several key plasma substrates were similar in both groups but epididymal fat pads 
      were heavier in VMNL.
FAU - Bernardis, L L
AU  - Bernardis LL
FAU - Luboshitsky, R
AU  - Luboshitsky R
FAU - Bellinger, L L
AU  - Bellinger LL
FAU - McEwen, G
AU  - McEwen G
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Adipose Tissue/pathology
MH  - Animals
MH  - *Diet
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Dietary Proteins/administration & dosage
MH  - Energy Intake
MH  - Fasting
MH  - Feeding and Eating Disorders/metabolism
MH  - *Food Preferences
MH  - Humans
MH  - Hypothalamus/*physiology
MH  - Hypothalamus, Middle/*physiology
MH  - Male
MH  - Obesity/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1982/07/01 00:00
MHDA- 1982/07/01 00:01
CRDT- 1982/07/01 00:00
PHST- 1982/07/01 00:00 [pubmed]
PHST- 1982/07/01 00:01 [medline]
PHST- 1982/07/01 00:00 [entrez]
AID - 10.1093/jn/112.7.1441 [doi]
PST - ppublish
SO  - J Nutr. 1982 Jul;112(7):1441-55. doi: 10.1093/jn/112.7.1441.