PMID- 6956869
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 79
IP  - 14
DP  - 1982 Jul
TI  - Serological analysis of cell surface antigens of null cell acute lymphocytic 
      leukemia by mouse monoclonal antibodies.
PG  - 4386-90
AB  - Nine antigens systems were defined. Two were related to HLA-A,B,C and to Ia-like 
      antigens; the others could be grouped into three categories. (i) NL-22, NL-1: 
      NL-22 antibody reacted with leukemia cells from 12 to 16 cases of null cell acute 
      lymphocytic leukemia (null-ALL) but not with any other type of leukemia tested or 
      with lymphoid cells of various origins. Among cultured cell lines tested, one 
      (NALM-6) of three null-ALL cell lines was positive, the others were negative. 
      Absorption analysis confirmed the restriction of NL-22 antigen to null-ALL. NL-1 
      antibody was reactive with leukemia cells from 10 to 16 cases of null-ALL and 3 
      of 6 cases of chronic myelocytic leukemia in blastic crisis (CML-BC). The antigen 
      was present also on a minor population of normal lymphoid cells. The distribution 
      and molecular weight (100,000; glycoprotein) of the NL-1 antigen resembled that 
      of the previously described common ALL antigen (cALL). (ii) NL-30, NL-4: Both 
      antibodies exhibited almost identical patterns of reactivities against cultured 
      cell lines tested. They reacted with leukemia cells from some cases of null-ALL, 
      adult T-cell leukemia, and CML-BC, although they showed discordance in their 
      reactivities against a panel of leukemia cells, (iii) NL-9, NL-8, NL-25: These 
      three antibodies detect serologically distinguishable determinants on a broad 
      range of leukemias and normal lymphoid and hematopoietic cell types. The 
      antibodies analyzed in this study provide evidence for the heterogeneity of 
      null-ALL by demonstrating a variety of antigen phenotypes on leukemia cells. One 
      of the antigens (NL-22) appears to be restricted to null-ALL.
FAU - Ueda, R
AU  - Ueda R
FAU - Tanimoto, M
AU  - Tanimoto M
FAU - Takahashi, T
AU  - Takahashi T
FAU - Ogata, S
AU  - Ogata S
FAU - Nishida, K
AU  - Nishida K
FAU - Namikawa, R
AU  - Namikawa R
FAU - Nishizuka, Y
AU  - Nishizuka Y
FAU - Ota, K
AU  - Ota K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Surface)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Antigens, Neoplasm/*analysis
MH  - Antigens, Surface/*analysis
MH  - Cell Line
MH  - Hematopoietic Stem Cells/immunology
MH  - Humans
MH  - Leukemia/immunology
MH  - Leukemia, Lymphoid/*immunology
MH  - Lymphocytes, Null/*immunology
MH  - Mice
PMC - PMC346676
EDAT- 1982/07/01 00:00
MHDA- 1982/07/01 00:01
PMCR- 1983/01/01
CRDT- 1982/07/01 00:00
PHST- 1982/07/01 00:00 [pubmed]
PHST- 1982/07/01 00:01 [medline]
PHST- 1982/07/01 00:00 [entrez]
PHST- 1983/01/01 00:00 [pmc-release]
AID - 10.1073/pnas.79.14.4386 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1982 Jul;79(14):4386-90. doi: 10.1073/pnas.79.14.4386.