PMID- 6965862
OWN - NLM
STAT- MEDLINE
DCOM- 19800523
LR  - 20190718
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 23
IP  - 3
DP  - 1980 Mar
TI  - Clinical and laboratory features of canine lupus syndromes.
PG  - 294-301
AB  - Determination of the specificities of antinuclear antibodies in the sera of 20 
      dogs presenting with symptoms of a lupus-like syndrome permitted their separation 
      into 2 groups. The first group of 14 dogs all had antibody activity to 
      DNA-histone antigen(s), and 4 of them also had antibodies to native DNA (nDNA). 
      The Farr test with standard buffer was found to be unsatisfactory for the 
      measurement of anti-nDNA antibodies in dog sera due to a high incidence of false 
      positive reactions; these could be eliminated by the inclusion of sodium dodecyl 
      sulfate in the buffer system. The second group of 6 dogs was characterized by the 
      presence of antibodies to extractable nuclear antigen. In every serum tested 
      diseased dogs had a diminished level of circulating thymic factor as compared to 
      controls of the same age, suggesting that a diminution of suppressor T cells may 
      be an etiologic factor.
FAU - Monier, J C
AU  - Monier JC
FAU - Dardenne, M
AU  - Dardenne M
FAU - Rigal, D
AU  - Rigal D
FAU - Costa, O
AU  - Costa O
FAU - Fournel, C
AU  - Fournel C
FAU - Lapras, M
AU  - Lapras M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 9007-49-2 (DNA)
RN  - 9H198D04WL (Thymic Factor, Circulating)
SB  - IM
MH  - Animals
MH  - Antibodies, Antinuclear/analysis
MH  - Antibody Specificity
MH  - Autoantibodies/analysis
MH  - DNA/immunology
MH  - *Dog Diseases/diagnosis/immunology
MH  - Dogs
MH  - False Positive Reactions
MH  - Female
MH  - Lupus Erythematosus, Systemic/diagnosis/immunology/*veterinary
MH  - Male
MH  - Thymic Factor, Circulating/analysis
EDAT- 1980/03/01 00:00
MHDA- 1980/03/01 00:01
CRDT- 1980/03/01 00:00
PHST- 1980/03/01 00:00 [pubmed]
PHST- 1980/03/01 00:01 [medline]
PHST- 1980/03/01 00:00 [entrez]
AID - 10.1002/art.1780230305 [doi]
PST - ppublish
SO  - Arthritis Rheum. 1980 Mar;23(3):294-301. doi: 10.1002/art.1780230305.