PMID- 696677
OWN - NLM
STAT- MEDLINE
DCOM- 19781202
LR  - 20190509
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 70
IP  - 1
DP  - 1978 Jul
TI  - A simple test for detection of sickle hemoglobin in the neonatal period.
PG  - 85-8
AB  - The ease of denaturation by shaking of a solution of oxyhemoglobin S (oxy-Hb S) 
      forms the basis for a simple and reliable test for confirmation or rapid 
      detection of Hb S in children and adults. Comparison of results of this test with 
      those from agar gel electrophoresis in capillary blood samples from 187 black 
      neonates at 2 to 7 days of life showed no overlap of the amounts of hemoglobin 
      precipitated between the group of neonates with Hb S (5.7--12.0%) and that 
      without Hb S (0--4.7%). These results indicate that the shaking test, by virtue 
      of being simple, reliable and inexpensive, may be used to detect and confirm Hb S 
      in large numbers of neonates before their discharge from the nursery.
FAU - Friedman, S
AU  - Friedman S
FAU - Back, B
AU  - Back B
FAU - Delivoria-Papadopoulos, M
AU  - Delivoria-Papadopoulos M
FAU - Atwater, J
AU  - Atwater J
FAU - Asakura, T
AU  - Asakura T
FAU - Schwartz, E
AU  - Schwartz E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Hemoglobin, Sickle)
RN  - 0 (Oxyhemoglobins)
SB  - IM
MH  - Anemia, Sickle Cell/diagnosis
MH  - Electrophoresis, Agar Gel
MH  - Hemoglobin, Sickle/*isolation & purification
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/diagnosis
MH  - Oxyhemoglobins
MH  - Spectrophotometry
EDAT- 1978/07/01 00:00
MHDA- 1978/07/01 00:01
CRDT- 1978/07/01 00:00
PHST- 1978/07/01 00:00 [pubmed]
PHST- 1978/07/01 00:01 [medline]
PHST- 1978/07/01 00:00 [entrez]
AID - 10.1093/ajcp/70.1.85 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 1978 Jul;70(1):85-8. doi: 10.1093/ajcp/70.1.85.