PMID- 6966821
OWN - NLM
STAT- MEDLINE
DCOM- 19800828
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 11
IP  - 5
DP  - 1980
TI  - Studies of anti-lymphocyte antibody in patients with active SLE. II. Effect of 
      anti-lymphocyte antibody on autoreactive cell clones.
PG  - 479-88
AB  - The effect of anti-lymphocyte antibodies of active systemic lupus erythematosus 
      (SLE) on the immune regulation of autoantibody production was studied. The 
      present study demonstrated that there were native DNA (nDNA)-sensitized T 
      lymphocytes even in inactive SLE and no or few nDNA-sensitized T lymphocytes in 
      normal individuals, and that in the inactive stages of SLE suppressor T 
      lymphocytes might inhibit the activation of nDNA-sensitized T lymphocytes 
      eliciting the production of anti-DNA antibodies by B lymphocytes. In the active 
      stage of SLE, the anti-lymphocyte antibodies could eliminate the suppressor 
      function of T lymphocytes or a subset of cells capable of either regulating their 
      appearance or differentiating into them, which inhibited such responses. The 
      different suppression of DNA and extractable nuclear antigen (ENA)-stimulated 
      blastogenic response is further discussed.
FAU - Morimoto, C
AU  - Morimoto C
FAU - Abe, T
AU  - Abe T
FAU - Toguchi, T
AU  - Toguchi T
FAU - Kiyotaki, M
AU  - Kiyotaki M
FAU - Homma, M
AU  - Homma M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Antigens)
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulins)
RN  - 9007-36-7 (Complement System Proteins)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antibodies, Antinuclear/*immunology
MH  - Antigens
MH  - Antilymphocyte Serum/*immunology
MH  - Autoantibodies/*biosynthesis/immunology
MH  - B-Lymphocytes/immunology
MH  - Clone Cells
MH  - Complement System Proteins/immunology
MH  - Cytotoxicity Tests, Immunologic
MH  - DNA/immunology/pharmacology
MH  - Humans
MH  - Immunoglobulins/biosynthesis
MH  - Lupus Erythematosus, Systemic/*immunology
MH  - Lymphocyte Activation
MH  - T-Lymphocytes/*immunology
EDAT- 1980/01/01 00:00
MHDA- 1980/01/01 00:01
CRDT- 1980/01/01 00:00
PHST- 1980/01/01 00:00 [pubmed]
PHST- 1980/01/01 00:01 [medline]
PHST- 1980/01/01 00:00 [entrez]
AID - 10.1111/j.1365-3083.1980.tb00016.x [doi]
PST - ppublish
SO  - Scand J Immunol. 1980;11(5):479-88. doi: 10.1111/j.1365-3083.1980.tb00016.x.