PMID- 6967490
OWN - NLM
STAT- MEDLINE
DCOM- 19801027
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 66
IP  - 3
DP  - 1980 Sep
TI  - Early-onset pauciarticular juvenile rheumatoid arthritis associated with human 
      leukocyte antigen-DRw5, iritis, and antinuclear antibody.
PG  - 426-9
AB  - Evidence has been sought for a genetically determined predisposition among 
      children with juvenile rheumatoid arthritis (JRA) who are also at particular risk 
      for the development of inflammatory eye disease.45 unrelated Caucasian patients 
      (41 female) with early-onset pauciarticular JRA were human leukocyte antigen 
      (HLA) types. 28 of the study group were found to be HLA-DRw5 compared with 16 of 
      84 controls (X(2), 24.3, P = <0.001). 9 patients were HLA-DRw8 compared with 4 of 
      84 controls (X(2), 7.51, P = <0.01). Iritis developed in 24 of the 45 children 
      studied, 17 of whom were typed as HLA-DRw5 when compared to controls (X(2), 
      26.76, P = <0.001) and 6 with iritis typed as HLA-DRw8 (X(2), 9.10, P = <0.01). 
      Antinuclear antibody was found in the serum of 17 of the 28 patients typing as 
      HLA-DRw5 compared with 4 of the 17 who did not have this antigen (X(2), 5.88, P = 
      <0.02). No such association was seen in patients with HLA-DRw8. In a study of 
      linked genes, a delta value of 0.090 was found for HLA-DRw5 with HLA-B12, of 
      0.070 for DRw5 with HLA-Cw4, and a value of 0.050 for DRw5 and HLA-Bw35. This 
      suggests a linkage disequilibrium between HLA-DRw5 and these two B series 
      alleles, a conclusion which was supported by haplotype analysis in families of 11 
      of the disease probands. HLA-DRw5 has not previously been reported to be 
      increased in any rheumatic disease group. It is proposed that HLA-DRw5 is a 
      genetic marker defining those at risk for early-onset pauciarticular JRA with 
      iritis.
FAU - Glass, D
AU  - Glass D
FAU - Litvin, D
AU  - Litvin D
FAU - Wallace, K
AU  - Wallace K
FAU - Chylack, L
AU  - Chylack L
FAU - Garovoy, M
AU  - Garovoy M
FAU - Carpenter, C B
AU  - Carpenter CB
FAU - Schur, P H
AU  - Schur PH
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Antibodies, Antinuclear/*analysis
MH  - Arthritis, Juvenile/complications/genetics/*immunology
MH  - Female
MH  - HLA Antigens/*analysis/classification
MH  - Haploidy
MH  - Humans
MH  - Iritis/*etiology/genetics/immunology
MH  - Male
PMC - PMC371669
EDAT- 1980/09/01 00:00
MHDA- 1980/09/01 00:01
PMCR- 1980/09/01
CRDT- 1980/09/01 00:00
PHST- 1980/09/01 00:00 [pubmed]
PHST- 1980/09/01 00:01 [medline]
PHST- 1980/09/01 00:00 [entrez]
PHST- 1980/09/01 00:00 [pmc-release]
AID - 10.1172/JCI109872 [doi]
PST - ppublish
SO  - J Clin Invest. 1980 Sep;66(3):426-9. doi: 10.1172/JCI109872.