PMID- 6968159
OWN - NLM
STAT- MEDLINE
DCOM- 19801124
LR  - 20190627
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 69
IP  - 3
DP  - 1980 Sep
TI  - Prospective study of immune response to hydralazine and development of 
      antideoxyribonucleoprotein in patients receiving hydralazine.
PG  - 395-400
AB  - To examine the relationship between the immune responses to hydralazine, a drug 
      known to induce systemic lupus erythematosus, and to deoxyribonucleoprotein (DNP) 
      we followed prospectively 21 hypertensive patients treated with hydralazine for 
      the first time. Within one year, antibodies to hydralazine developed in 16 of 
      these patients and anti-DNP in seven of these. In one patient whose serum had a 
      positive antinuclear antibody test prior to treatment, a mild hydralazine 
      systemic lupus erythematosus syndrome developed preceded by rises in the levels 
      of both anti-hydralazine and anti-DNP. Studies by radioimmunoassay on serums of 
      three additional patients, not followed in this study but known to have 
      hydralazine-induced systemic lupus erythematosus, revealed no evidence for either 
      (1) cross-reactivity between anti-DNP and anti-hydralazine or (2) antibodies 
      specific for a hydralazine-DNP complex. In some way, perhaps related to the 
      mechanism by which carrier molecules enhance the immunogenuity of haptens, 
      hydralazine increases the antigenicity of DNP. This effect depends on the 
      development of immunity to hydralazine as well.
FAU - Carpenter, J R
AU  - Carpenter JR
FAU - McDuffie, F C
AU  - McDuffie FC
FAU - Sheps, S G
AU  - Sheps SG
FAU - Spiekerman, R E
AU  - Spiekerman RE
FAU - Brumfield, H
AU  - Brumfield H
FAU - King, R
AU  - King R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Antibodies)
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Deoxyribonucleoproteins)
RN  - 0 (Nucleoproteins)
RN  - 0 (deoxyribonucleoprotein antibodies)
RN  - 26NAK24LS8 (Hydralazine)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Antibodies/analysis
MH  - Antibodies, Antinuclear/*analysis
MH  - *Antibody Formation
MH  - DNA/immunology
MH  - Deoxyribonucleoproteins/*immunology
MH  - Humans
MH  - Hydralazine/adverse effects/*immunology
MH  - Hypertension/drug therapy
MH  - Lupus Erythematosus, Systemic/chemically induced
MH  - Nucleoproteins/*immunology
MH  - Prospective Studies
EDAT- 1980/09/01 00:00
MHDA- 1980/09/01 00:01
CRDT- 1980/09/01 00:00
PHST- 1980/09/01 00:00 [pubmed]
PHST- 1980/09/01 00:01 [medline]
PHST- 1980/09/01 00:00 [entrez]
AID - 0002-9343(80)90010-8 [pii]
AID - 10.1016/0002-9343(80)90010-8 [doi]
PST - ppublish
SO  - Am J Med. 1980 Sep;69(3):395-400. doi: 10.1016/0002-9343(80)90010-8.