PMID- 6971959
OWN - NLM
STAT- MEDLINE
DCOM- 19810709
LR  - 20071114
IS  - 0023-6837 (Print)
IS  - 0023-6837 (Linking)
VI  - 44
IP  - 5
DP  - 1981 May
TI  - Mechanism of potentiation of experimental Haemophilus influenzae type B disease 
      in infant rats by influenza A virus.
PG  - 434-41
AB  - Intranasal infection of infant rats by virulent influenza A virus increases the 
      frequency and magnitude of bacteremia induced by subsequent atraumatic intranasal 
      inoculation of Haemophilus influenzae type b (HIb). The mechanism of the 
      "potentiating" effect was studied by histology, by measurement of the frequency 
      and kinetics of bacteremia in rats preinoculated with virus, or a chemical 
      irritant (0.1 N HCl), by comparison of the latter with physically "traumatic" 
      bacterial inoculation, and correlation of these data with nasal HIb titers. Both 
      virus and acid induced significant nasal inflammation which progressed following 
      bacterial inoculation. A period of intranasal proliferation of HIb preceded 
      bacteremia in rats preinoculated with either virus or acid. In contrast, 
      bacteremia occurred almost immediately following physically traumatic bacterial 
      inoculation suggesting that direct intravascular invasion had occurred under 
      those circumstances. Repeated atraumatic inoculation of HIb or HIb followed by 
      growth medium both produced a significantly increased frequently of bacteremia 
      compared to a single inoculation, suggesting that the prolonged presence of large 
      numbers of intranasal HIb was a factor in producing bacteremia and that virus or 
      acid-induced mucosal inflammation may lead to elaboration of growth factors for 
      HIb in nasal tissues.
FAU - Myerowitz, R L
AU  - Myerowitz RL
FAU - Michaels, R H
AU  - Michaels RH
LA  - eng
GR  - R01-AI-11932-04/AI/NIAID NIH HHS/United States
GR  - R01-AI-15988-01/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Lab Invest
JT  - Laboratory investigation; a journal of technical methods and pathology
JID - 0376617
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Haemophilus Infections/complications/*microbiology
MH  - Haemophilus influenzae
MH  - Inflammation/microbiology
MH  - Nasal Mucosa/pathology
MH  - Orthomyxoviridae Infections/*complications
MH  - Rats
MH  - Sepsis/etiology
EDAT- 1981/05/01 00:00
MHDA- 1981/05/01 00:01
CRDT- 1981/05/01 00:00
PHST- 1981/05/01 00:00 [pubmed]
PHST- 1981/05/01 00:01 [medline]
PHST- 1981/05/01 00:00 [entrez]
PST - ppublish
SO  - Lab Invest. 1981 May;44(5):434-41.