PMID- 6980239
OWN - NLM
STAT- MEDLINE
DCOM- 19820924
LR  - 20190817
IS  - 0192-0790 (Print)
IS  - 0192-0790 (Linking)
VI  - 4
IP  - 3
DP  - 1982 Jun
TI  - Alpha-1-antitrypsin deficiency--a cause of cryptogenic liver disease in the 
      elderly.
PG  - 269-73
AB  - We report a 73-year-old woman with homozygous ZZ alpha-1-antitrypsin deficiency 
      (AATD), micronodular cirrhosis, cholestatic jaundice, and emphysema. An elevated 
      SGOT/SGPT ratio was noted in the absence of chronic alcoholism. ERCP demonstrated 
      a normal extrahepatic biliary system and suggested obstruction of the 
      intrahepatic ducts. An operative liver biopsy demonstrated periodic 
      acid-Schiff-positive, diastase resistant intracytoplasmic inclusion bodies. This 
      patient reminds us that metabolic causes of cryptogenic liver disease need to be 
      considered, even in the elderly. We review briefly the literature concerning AATD 
      and liver disease.
FAU - Battle, W M
AU  - Battle WM
FAU - Matarazzo, S A
AU  - Matarazzo SA
FAU - Selhat, G F
AU  - Selhat GF
FAU - Catalano, E
AU  - Catalano E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Gastroenterol
JT  - Journal of clinical gastroenterology
JID - 7910017
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Female
MH  - Humans
MH  - Liver/pathology
MH  - Liver Cirrhosis/*etiology
MH  - Liver Function Tests
MH  - Phenotype
MH  - alpha 1-Antitrypsin/genetics
MH  - *alpha 1-Antitrypsin Deficiency
EDAT- 1982/06/01 00:00
MHDA- 1982/06/01 00:01
CRDT- 1982/06/01 00:00
PHST- 1982/06/01 00:00 [pubmed]
PHST- 1982/06/01 00:01 [medline]
PHST- 1982/06/01 00:00 [entrez]
AID - 10.1097/00004836-198206000-00014 [doi]
PST - ppublish
SO  - J Clin Gastroenterol. 1982 Jun;4(3):269-73. doi: 
      10.1097/00004836-198206000-00014.