PMID- 6981598
OWN - NLM
STAT- MEDLINE
DCOM- 19821202
LR  - 20190829
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 16
IP  - 1
DP  - 1982
TI  - Cell-mediated cytotoxicity to non-MHC alloantigens on mouse epidermal cells. VI. 
      Influence of the MHC on the tissue specificity of cytotoxic T-lymphocyte 
      responses.
PG  - 23-36
AB  - Mice of the C3H/He and A non-H-2 backgrounds are disparate from mice of the B10 
      background for the tissue-restricted, non-H-2 alloantigen of epidermal cells 
      (EC), Epa-1, that is expressed by EC but not by lymphocytes (LC), as well as for 
      a number of other alloantigens of the B10 background that are expressed by both 
      EC and LC, generically referred to as "lymphocyte/epidermal alloantigens" (LEA). 
      In this study, we compared the ability of various H-2 congenic strains on the C3H 
      or A backgrounds to mount cytotoxic T-lymphocyte (CTL) responses to EC from H-2 
      compatible mice of the B10 background. High responses to Epa-1 were detected only 
      in the H-2a and H-2k haplotypes; H-2b, H-2o1, H-2s, H-2t1, and H-2t2 haplotypes 
      were nonresponders to Epa-1. High responses to LEA were detected in H-2a, H-2b, 
      H-2s, H-2t1, and H-2t2 haplotypes; H-2k and H-2o1 were nonresponsive to LEA. 
      Analysis of the H-2K, I and D region alleles of responders indicates that H-2Kk 
      is essential for anti-Epa CTL responses, whereas Dd, Db or Ks were all permissive 
      for strong anti-LEA responses. The ability to mount a given CTL response was not 
      associated with differences in I-region alleles. These results are discussed in 
      terms of K/D region products serving as Ir-gene products for CTL and in 
      determining the apparent tissue-specificity of CTL.
FAU - Tyler, J D
AU  - Tyler JD
FAU - Burlingham, W J
AU  - Burlingham WJ
FAU - David, C S
AU  - David CS
FAU - Steinmuller, D
AU  - Steinmuller D
LA  - eng
GR  - AM 26783/AM/NIADDK NIH HHS/United States
GR  - CA 09127/CA/NCI NIH HHS/United States
GR  - CA 24473/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (H-2 Antigens)
RN  - 0 (Isoantigens)
SB  - IM
MH  - Animals
MH  - *Cytotoxicity, Immunologic
MH  - H-2 Antigens
MH  - In Vitro Techniques
MH  - Isoantigens/*immunology
MH  - *Major Histocompatibility Complex
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Skin/*immunology
MH  - T-Lymphocytes/*immunology
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1007/BF00364439 [doi]
PST - ppublish
SO  - Immunogenetics. 1982;16(1):23-36. doi: 10.1007/BF00364439.