PMID- 6986186
OWN - NLM
STAT- MEDLINE
DCOM- 19800423
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 184
IP  - 2
DP  - 1980 Feb 24
TI  - Acute central stimulation of luteinizing hormone by parenterally administered 
      N-methyl-D,L-aspartic acid in the male rat.
PG  - 425-37
AB  - N-methyl-D,L-aspartic acid (NMA), a potent neuroexcitatory and neurotoxic 
      glutamic acid analogue, acutely elevated serum luteinizing hormone (LH) in male 
      rats when given subcutaneously in doses below those that cause morphologically 
      detectable hypothalamic neurotoxicity. NMA treatment in doses known to be 
      subtoxic by morphological criteria fails to induce any permanent neuroendocrine 
      dysfunction as assessed by several physiological parameters, including NMA 
      responsiveness after multiple consecutive dosees spaced at 24 h intervals, 
      subsequent basal LH levels and subsequent postcastration LH elevations. Like 
      naloxone, NMA elevates serum LH by reversibly stimulating a central labile pool. 
      Neither has a direct stimulatory effect on the pituitary in vitro. Treatment with 
      either attenuates naloxone-induced LH stimulation 2 h, but not 14 days, later 
      while pituitary responsiveness to LHRH in vivo remains unaltered. Neither NMA nor 
      naloxone is dependent upon testosterone for its LH stimulatory action and both 
      increase serum LH through physiological mechanisms responsive to testosterone 
      inhibition. It is concluded that subtoxic LH stimulating doses of NMA provide a 
      useful tool in discerning neurotransmitter systems involved in central control of 
      the hypothalamic-pituitary-gonadal axis.
FAU - Schainker, B A
AU  - Schainker BA
FAU - Cicero, T J
AU  - Cicero TJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 36B82AMQ7N (Naloxone)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - Aspartic Acid/*analogs & derivatives/pharmacology
MH  - Castration
MH  - Dose-Response Relationship, Drug
MH  - Gonadotropin-Releasing Hormone/pharmacology
MH  - Kinetics
MH  - Luteinizing Hormone/blood/*metabolism
MH  - Male
MH  - Naloxone/pharmacology
MH  - Pituitary Gland/drug effects/*metabolism
MH  - Rats
EDAT- 1980/02/24 00:00
MHDA- 1980/02/24 00:01
CRDT- 1980/02/24 00:00
PHST- 1980/02/24 00:00 [pubmed]
PHST- 1980/02/24 00:01 [medline]
PHST- 1980/02/24 00:00 [entrez]
AID - 0006-8993(80)90810-0 [pii]
AID - 10.1016/0006-8993(80)90810-0 [doi]
PST - ppublish
SO  - Brain Res. 1980 Feb 24;184(2):425-37. doi: 10.1016/0006-8993(80)90810-0.