PMID- 6986255
OWN - NLM
STAT- MEDLINE
DCOM- 19800417
LR  - 20131121
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 106
IP  - 2
DP  - 1980 Feb
TI  - Priming of estrous responsiveness by implants of 17 beta-estradiol in the 
      ventromedial hypothalamic nucleus of female rats.
PG  - 504-9
AB  - In an attempt to obtain a more precise localization of the neural target site(s) 
      of estrogen-priming action in the activation of estrous behavior, 30-gauge 
      cannulae containing a preparation of 17 beta-estradiol diluted 1:250 with 
      cholesterol were implanted bilaterally into the brains of ovariectomized rats. 
      Subjects were tested for sexual behavior with intact males at 4-day intervals for 
      3 weeks beginning 2-3 days after stereotaxic surgery. Animals received a systemic 
      injection of 0.5 mg progesterone 4-6 h before all but 1 test. After this 
      treatment, estrous behavior was observed in 19 of the 20 animals judged to have 
      both cannulae resting in or within 0.25 mm of the ventromedial nucleus of the 
      hypothalamus (VMN). Virtually no estrous behavior was observed without the 
      administration of progesterone. Behavioral scores decreased as a function of the 
      distance of the cannulae tips from the VMN. Cholesterol implants in the same 
      region (n = 8) were without effect. Implants in other regions of the brain (e.g. 
      preoptic area, diagonal band of Broca, lateral habenula, amygdala, or cortex; n = 
      52) were ineffective. These results indicate that estrogenic stimulation of the 
      region of the VMN alone is sufficient to prime the activation of estrous behavior 
      in the ovariectomized rat.
FAU - Rubin, B S
AU  - Rubin BS
FAU - Barfield, R J
AU  - Barfield RJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Drug Implants)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Castration
MH  - Cerebral Cortex/drug effects/physiology
MH  - Drug Implants
MH  - Estradiol/*pharmacology
MH  - Female
MH  - Hypothalamus/*physiology
MH  - Organ Specificity
MH  - Rats
MH  - Sexual Behavior, Animal/*drug effects
MH  - Stereotaxic Techniques
EDAT- 1980/02/01 00:00
MHDA- 1980/02/01 00:01
CRDT- 1980/02/01 00:00
PHST- 1980/02/01 00:00 [pubmed]
PHST- 1980/02/01 00:01 [medline]
PHST- 1980/02/01 00:00 [entrez]
AID - 10.1210/endo-106-2-504 [doi]
PST - ppublish
SO  - Endocrinology. 1980 Feb;106(2):504-9. doi: 10.1210/endo-106-2-504.