PMID- 6986562
OWN - NLM
STAT- MEDLINE
DCOM- 19800417
LR  - 20190617
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 283
IP  - 5747
DP  - 1980 Feb 7
TI  - LH-RH in the mesencephalic central grey can potentiate lordosis reflex of female 
      rats.
PG  - 566-7
AB  - The lordosis reflex, which characterises female reproductive behaviour in 
      rodents, can be potentiated in oestrogen-primed ovariectomised female rats by 
      electrical stimulation of the ventromedial nucleus of the hypothalamus (VMN). 
      Subsequent demonstration of an immediate and large facilitation of the lordosis 
      reflex from the mesencephalic central grey (CG) prompted us to speculate that the 
      VMN may exert an oestrogen-dependent tonic bias on the mesencephalic circuitry 
      for lordosis via its heavy descending projections. Moreover, we considered that 
      luteinising hormone-releasing hormone (LH-RH) could be involved in this system. 
      LH-RH can potentiate lordosis when given systemically to oestrogen-primed 
      ovariectomised rats, and neurotropic effects of this peptide have been shown by 
      microiontophoresis. Also, some axons in the CG have been stained with antiserum 
      to LH-RH. The present study examined a possible role of LH-RH in the CG in the 
      regulation of the lordosis reflex of oestrogen-primed ovariectomised female rats. 
      Infusion of exogenous LH-RH in the CG had an immediate facilitative effect on the 
      lordosis reflex, whereas passive immunisation against endogenous LH-RH by 
      anti-LH-RH gamma-globulin diminished the reflex.
FAU - Sakuma, Y
AU  - Sakuma Y
FAU - Pfaff, D W
AU  - Pfaff DW
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Female
MH  - Gonadotropin-Releasing Hormone/immunology/*pharmacology
MH  - Immunologic Techniques
MH  - Mesencephalon/*drug effects
MH  - Rats
MH  - Sexual Behavior, Animal/*drug effects
EDAT- 1980/02/07 00:00
MHDA- 1980/02/07 00:01
CRDT- 1980/02/07 00:00
PHST- 1980/02/07 00:00 [pubmed]
PHST- 1980/02/07 00:01 [medline]
PHST- 1980/02/07 00:00 [entrez]
AID - 10.1038/283566a0 [doi]
PST - ppublish
SO  - Nature. 1980 Feb 7;283(5747):566-7. doi: 10.1038/283566a0.