PMID- 6990633
OWN - NLM
STAT- MEDLINE
DCOM- 19800726
LR  - 20181113
IS  - 0044-0086 (Print)
IS  - 1551-4056 (Electronic)
IS  - 0044-0086 (Linking)
VI  - 53
IP  - 1
DP  - 1980 Jan-Feb
TI  - Types of immunological failure in the "slow-virus" encephalopathies and multiple 
      sclerosis.
PG  - 101-7
AB  - The pathogenesis of the slow virus encephalopathies and multiple sclerosis is 
      reviewed within the framework of the immune response. The diseases are analyzed 
      for the component of the immune response that appears to be crucial to the host's 
      failure to control the disease. Thus, the absence of an immune response in the 
      spongiform encephalopathies appears to reflect a failure of antigen recognition. 
      Progressive multifocal leukoencephalopathy (PML), subacute sclerosing 
      panencephalitis (SSPE), and progressive rubella panencephalitis (PRP) may result 
      principally from a failure of effector mechanisms. In PML the failure usually 
      occurs within the setting of an immunosuppressive illness. Conversely, in SSPE 
      and PRP the effector failure seems to result from the nature of the host-virus 
      interaction itself. Finally, evidence is accumulating that a defect of 
      immunoregulation plays a significant role in multiple sclerosis.
FAU - Booss, J
AU  - Booss J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Yale J Biol Med
JT  - The Yale journal of biology and medicine
JID - 0417414
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Antigens, Viral/immunology
MH  - Creutzfeldt-Jakob Syndrome/immunology
MH  - Encephalitis/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Kuru/immunology
MH  - Leukoencephalopathy, Progressive Multifocal/immunology
MH  - Multiple Sclerosis/*immunology
MH  - Slow Virus Diseases/*immunology
MH  - Subacute Sclerosing Panencephalitis/immunology
PMC - PMC2595833
EDAT- 1980/01/01 00:00
MHDA- 1980/01/01 00:01
PMCR- 1980/01/01
CRDT- 1980/01/01 00:00
PHST- 1980/01/01 00:00 [pubmed]
PHST- 1980/01/01 00:01 [medline]
PHST- 1980/01/01 00:00 [entrez]
PHST- 1980/01/01 00:00 [pmc-release]
PST - ppublish
SO  - Yale J Biol Med. 1980 Jan-Feb;53(1):101-7.