PMID- 6990967
OWN - NLM
STAT- MEDLINE
DCOM- 19800828
LR  - 20190719
IS  - 0007-1145 (Print)
IS  - 0007-1145 (Linking)
VI  - 43
IP  - 2
DP  - 1980 Mar
TI  - Carbohydrate utilization in obese subjects after an oral load of 100 g 
      naturally-labelled [13C] glucose.
PG  - 281-8
AB  - 1. Total carbohydrate (CHO) and ingested glucose oxidation was measured in five 
      obese subjects with normal glucose tolerance after an oral load of 100 g 
      naturally-labelled [13C]glucose using indirect calorimetry and mass spectrometry 
      respectively. 2. CHO utilization rate (107 +/- 14 mg/min in the post-absorptive 
      state) increased 30 min after the glucose load to reach a plateau (245 +/- 25 
      mg/min) between 90 and 120 min. It then decreased to basal values at 330 min. 
      Cumulative CHO oxidation over 480 min was 66 +/- 7 g and the CHO oxidized above 
      basal levels was 26 +/- 7 g. 3. Enrichment of expired carbon dioxide with 13C 
      began at 45 min and maximum values were observed between 210 and 300 min. At 480 
      min, cumulative oxidation of the ingested glucose was 24 +/- 2 g. 4. Compared 
      with controls, the obese subjects exhibit an impairment of CHO utilization which 
      precedes glucose intolerance. This impairment can be explained by an increased 
      availability of free fatty acids which favours lipid oxidation at the expense of 
      ingested [13C]glucose oxidation.
FAU - Ravussin, E
AU  - Ravussin E
FAU - Doerner, A
AU  - Doerner A
FAU - Acheson, K J
AU  - Acheson KJ
FAU - Pahud, P
AU  - Pahud P
FAU - Arnaud, M J
AU  - Arnaud MJ
FAU - Jequier, E
AU  - Jequier E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Blood Glucose)
RN  - 0 (Carbon Isotopes)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Carbon Isotopes
MH  - Dietary Carbohydrates/*metabolism
MH  - Fatty Acids, Nonesterified/blood
MH  - Glucose/*metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Obesity/*metabolism
MH  - Oxidation-Reduction
MH  - Time Factors
EDAT- 1980/03/01 00:00
MHDA- 1980/03/01 00:01
CRDT- 1980/03/01 00:00
PHST- 1980/03/01 00:00 [pubmed]
PHST- 1980/03/01 00:01 [medline]
PHST- 1980/03/01 00:00 [entrez]
AID - S0007114580000360 [pii]
AID - 10.1079/bjn19800091 [doi]
PST - ppublish
SO  - Br J Nutr. 1980 Mar;43(2):281-8. doi: 10.1079/bjn19800091.