PMID- 6992231
OWN - NLM
STAT- MEDLINE
DCOM- 19800828
LR  - 20190825
IS  - 0090-6980 (Print)
IS  - 0090-6980 (Linking)
VI  - 19
IP  - 4
DP  - 1980 Apr
TI  - Generation of prostacyclin-like substance and lipid peroxidation in vitamin 
      E-deficient rats.
PG  - 527-36
AB  - Endogenous generation of prostacyclin (PGI2)-like substance and lipid 
      peroxidation were studied in the aorta of rats fed on vitamin E-deficient diet 
      and/or vitamin E-supplemented one for 4 to 10 months after they were weaned at 4 
      weeks. PGI2-like substance was produced by the incubation of the aortic ring in 
      pH 9.0 borate-buffered saline and was estimated by comparison of its 
      antiaggregatory activity with that produced by known amounts of synthetic PGI2. 
      Thiobarbituric acid-reacting substance (TBARS) was determined as an indicator of 
      lipid peroxidation. The generation of PGI2-like substance was significantly 
      reduced in rats fed on vitamin E-deficient diet for 8 and 10 months as compared 
      with that in the animals fed on vitamin E-supplemented one for the same period (p 
      less than 0.001). Mean concentration of TBARS in the aortae of rats fed on 
      vitamin E-deficient diet for 10 months was significantly higher than that of the 
      animals fed on vitamin E-supplemented diet for the same feeding period (p less 
      than 0.001). These alterations in the aortae of rats fed on vitamin E-deficient 
      diet were corrected by feeding them on vitamin E-supplemented diet for subsequent 
      2 months.
FAU - Okuma, M
AU  - Okuma M
FAU - Takayama, H
AU  - Takayama H
FAU - Uchino, H
AU  - Uchino H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Prostaglandins
JT  - Prostaglandins
JID - 0320271
RN  - 0 (Lipid Peroxides)
RN  - 0 (Prostaglandins)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Animals
MH  - Aorta/metabolism
MH  - Epoprostenol/*biosynthesis
MH  - In Vitro Techniques
MH  - Lipid Peroxides/*metabolism
MH  - Male
MH  - Prostaglandins/*biosynthesis
MH  - Rats
MH  - Vitamin E Deficiency/*metabolism
EDAT- 1980/04/01 00:00
MHDA- 1980/04/01 00:01
CRDT- 1980/04/01 00:00
PHST- 1980/04/01 00:00 [pubmed]
PHST- 1980/04/01 00:01 [medline]
PHST- 1980/04/01 00:00 [entrez]
AID - S0090-6980(80)80003-7 [pii]
AID - 10.1016/s0090-6980(80)80003-7 [doi]
PST - ppublish
SO  - Prostaglandins. 1980 Apr;19(4):527-36. doi: 10.1016/s0090-6980(80)80003-7.