PMID- 6997025
OWN - NLM
STAT- MEDLINE
DCOM- 19801125
LR  - 20190829
IS  - 0013-7219 (Print)
IS  - 0013-7219 (Linking)
VI  - 27
IP  - 2
DP  - 1980 Apr
TI  - Comparison of the effect of electrochemical stimulation of the medial preoptic 
      area and the hypothalamic arcuate nucleus upon LH release in ovariectomized and 
      proestrous rats.
PG  - 239-46
AB  - The effect of electrochemical stimulation of the medial preoptic area (MPO) and 
      the hypothalamic arcuate nucleus (ARC) on LH release was compared among long-term 
      ovariectomized (OVX), ovariectomized rats treated with estradiol benzoate (OVX-E) 
      and proestrous (PE) rats under pentobarital anesthesia. The MPO stimulation 
      failed to facilitate LH release on OVX rats whereas the stimulation increased 
      serum LH levels in both OVX-E and PE rats. The ARC stimulation resulted in an 
      elevation of serum LH in OVX and PE rats. The time course of serum LH elevation 
      after the electrochemical stimulation of the MPO or the ARC was different between 
      OVX-E and PE rats. In PE rats serum LH concentrations began to rise 20-30 min 
      after the stimulation of the MPO or the ARC with peak values obtained around 
      70-90 min. Serum LH started to elevate immediately with peak values in 10-20 min 
      following the ARC stimulation in OVX rats and the MPO stimulation in OVX-E rats. 
      The time courses for changes in serum LH concentrations following LH-RH 
      administration were similar in OVX and PE rats. From these results, the lack of 
      circadian rhythm in serum LH levels in long-term OVX rats may be due to the 
      inability of the MPO to re- spond to the stimulus generated from circadian 
      pacemaker(s). The cause of the delay observed between the stimulation of the MPO 
      and LH rise in PE rats may not exist in the levels of neural transmission between 
      the MPO and the ARC or the pituitary, but in the level of the mediobasal 
      hypothalamus.
FAU - Kawakami, M
AU  - Kawakami M
FAU - Higuchi, T
AU  - Higuchi T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Endocrinol Jpn
JT  - Endocrinologia japonica
JID - 0376546
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - *Castration
MH  - Electric Stimulation
MH  - Estradiol/pharmacology
MH  - *Estrus
MH  - Female
MH  - Gonadotropin-Releasing Hormone/pharmacology
MH  - Hypothalamus/drug effects/*metabolism/*physiology
MH  - Luteinizing Hormone/*metabolism
MH  - Pregnancy
MH  - Preoptic Area/drug effects/*physiology
MH  - *Proestrus
MH  - Rats
MH  - Stimulation, Chemical
EDAT- 1980/04/01 00:00
MHDA- 1980/04/01 00:01
CRDT- 1980/04/01 00:00
PHST- 1980/04/01 00:00 [pubmed]
PHST- 1980/04/01 00:01 [medline]
PHST- 1980/04/01 00:00 [entrez]
AID - 10.1507/endocrj1954.27.239 [doi]
PST - ppublish
SO  - Endocrinol Jpn. 1980 Apr;27(2):239-46. doi: 10.1507/endocrj1954.27.239.