PMID- 7001925
OWN - NLM
STAT- MEDLINE
DCOM- 19810129
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 239
IP  - 5
DP  - 1980 Nov
TI  - Shigella dysenteriae I enterotoxin: proposed role in pathogenesis of shigellosis.
PG  - G382-6
AB  - Bacterial strains of Shigella dysenteriae I (3818-T and 3818-O) and Shigella 
      enterotoxin altered myoelectric activity of the small intestine in New Zealand 
      White rabbits. These agents were compared with activity caused by sterile culture 
      broth or sterile saline. The altered myoelectric activity was characterized by 
      two distinct complexes: repetitive bursts of action potentials (RBAP), 
      characteristic of invasive strains of bacteria, and the migrating action 
      potential complex (MAPC), characteristic of noninvasive bacteria. RBAP activity 
      was the predominant myoelectric complex observed with S. dysenteriae strain 
      3818-T, an invader and toxin producer; S. dysenteriae strain 3818-O, a noninvader 
      and toxin producer; and by Shigella enterotoxin. MAPC activity was present but 
      was significantly less in all cases. These studies of the small intestine 
      demonstrate an alteration in myoelectric activity characterized principally by 
      RBAP activity indicative of invasion.
FAU - Mathias, J R
AU  - Mathias JR
FAU - Carlson, G M
AU  - Carlson GM
FAU - Martin, J L
AU  - Martin JL
FAU - Shields, R P
AU  - Shields RP
FAU - Formal, S
AU  - Formal S
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
SB  - IM
MH  - Action Potentials/*drug effects
MH  - Animals
MH  - Bacterial Toxins/*pharmacology
MH  - Dysentery, Bacillary/*microbiology
MH  - Electrophysiology
MH  - Enterotoxins/*pharmacology
MH  - Gastrointestinal Motility/drug effects
MH  - Ileum/*physiology
MH  - In Vitro Techniques
MH  - Rabbits
MH  - Shigella dysenteriae
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
AID - 10.1152/ajpgi.1980.239.5.G382 [doi]
PST - ppublish
SO  - Am J Physiol. 1980 Nov;239(5):G382-6. doi: 10.1152/ajpgi.1980.239.5.G382.