PMID- 7003424
OWN - NLM
STAT- MEDLINE
DCOM- 19810219
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 31
IP  - 5
DP  - 1980 Nov
TI  - Components of the renin-angiotensin system in the cerebrospinal fluid of rats and 
      dogs with special consideration of the origin and the fate of angiotensin II.
PG  - 297-308
AB  - From the in vitro and in vivo measurements of the components of the 
      renin-angiotensin system (RAS) in the cerebrospinal fluid (CSF) of rats and dogs, 
      it was concluded that angiotension II (ANG II) is not generated within the CSF in 
      significant amounts, since renin was found to be unmeasurable in CSF under most 
      circumstances. The specific concentrations of angiotensinogen and of converting 
      enzyme (CE) were high. Angiotensin I (ANG I) concentrations were low in CSF, 
      while ANG II levels were comparable to those measured in plasma under control 
      conditions. Neither ANG I nor ANG II penetrated from the blood into the brain 
      ventricles of rats, provided that no unrealistically high doses of ANG II were 
      administered intravenously. This holds true even if high blood pressure increases 
      were induced by intravenous ANG II infusion in deoxycorticosterone acetate (DOCA) 
      and salt-treated rats. However, increased ANG II concentrations were measured in 
      CSF perfusate, when the blood-brain barrier (BBB) was opened by the intracarotid 
      injection of a hyperosmolar urea solution. The brain ventricular perfusion of 
      increasing concentrations of ANG II revealed constant recovery of less than 40%. 
      CSF did not contain angiotensinase activity, but ANG II degradation was high in 
      some periventricular regions. ANG II, the ANG II antagonist saralasin, and the CE 
      inhibitor captopril, respectively, escaped from CSF into circulation when high 
      doses of these substances were applied intraventricularly. We conclude that ANG 
      II in the CSF does not originate from and is not related to plasma ANG II. It is 
      probably not generated within the CSF. ANG II may be synthetized in the brain 
      tissue and be released into the brain ventricles where its rapid degradation 
      occurs in contact with circumventricular structures.
FAU - Schelling, P
AU  - Schelling P
FAU - Ganten, U
AU  - Ganten U
FAU - Sponer, G
AU  - Sponer G
FAU - Unger, T
AU  - Unger T
FAU - Ganten, D
AU  - Ganten D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 11002-13-4 (Angiotensinogen)
RN  - 11128-99-7 (Angiotensin II)
RN  - 9041-90-1 (Angiotensin I)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Angiotensin I/cerebrospinal fluid
MH  - Angiotensin II/blood/*cerebrospinal fluid
MH  - Angiotensinogen/cerebrospinal fluid
MH  - Animals
MH  - Blood-Brain Barrier
MH  - Brain Chemistry
MH  - Dogs
MH  - In Vitro Techniques
MH  - Male
MH  - Rats
MH  - Renin/*cerebrospinal fluid
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
AID - 10.1159/000123092 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1980 Nov;31(5):297-308. doi: 10.1159/000123092.