PMID- 7004181
OWN - NLM
STAT- MEDLINE
DCOM- 19810224
LR  - 20220318
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 69
IP  - 6
DP  - 1980 Dec
TI  - Immunopathology of cardiac lesions in fatal systemic lupus erythematosus.
PG  - 849-58
AB  - Immunopathologic studies were performed on cardiac tissue obtained at autopsy in 
      10 patients with severe systemic lupus erythematosus (SLE). The immunopathologic 
      findings were correlated with histopathologic and clinical evidence of cardiac 
      injury, and with clinical and serologic features of SLE. Immune reactants were 
      demonstrated by direct immunofluorescence in nine patients in a granular 
      deposition pattern suggesting immune complex aggregates. Histologic and gross 
      anatomic findings of inflammation were generally more focal than was the 
      distribution of immune reactants. Most of the immune deposits were present in the 
      walls of the blood vessels of myocardium (eight of 10) or pericardium (two of 
      three). In one patient with Libman-Sacks endocarditis, immunoglobulin and 
      complement components were present in the valve stroma and the vegetations. The 
      immune deposits around epicardial nerve fibers in two patients with severe 
      neurologic manifestations contained immunoglobulin E(IgE). In general, the most 
      intense and widespread immune deposits were observed in patients with 
      persistently increased serologic and clinical evidence of activity of their 
      systemic disease. These results suggest a role for immune complex deposition in 
      the pathogenesis of the cardiac lesions of SLE.
FAU - Bidani, A K
AU  - Bidani AK
FAU - Roberts, J L
AU  - Roberts JL
FAU - Schwartz, M M
AU  - Schwartz MM
FAU - Lewis, E J
AU  - Lewis EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Antigen-Antibody Complex)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antigen-Antibody Complex/analysis
MH  - Endocarditis/pathology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Lupus Erythematosus, Systemic/immunology/*pathology
MH  - Male
MH  - Myocardium/immunology/*pathology
MH  - Pericarditis/pathology
EDAT- 1980/12/01 00:00
MHDA- 1980/12/01 00:01
CRDT- 1980/12/01 00:00
PHST- 1980/12/01 00:00 [pubmed]
PHST- 1980/12/01 00:01 [medline]
PHST- 1980/12/01 00:00 [entrez]
AID - S0002-9343(80)80010-6 [pii]
AID - 10.1016/s0002-9343(80)80010-6 [doi]
PST - ppublish
SO  - Am J Med. 1980 Dec;69(6):849-58. doi: 10.1016/s0002-9343(80)80010-6.