PMID- 7004622
OWN - NLM
STAT- MEDLINE
DCOM- 19810324
LR  - 20190620
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 46
IP  - 12
DP  - 1980 Dec 15
TI  - Differential diagnosis of malignant lymphoma and nonlymphoid tumors using 
      monoclonal anti-leucocyte antibody.
PG  - 2640-7
AB  - Pathologic samples from 34 cases of human solid malignancies were tested for 
      reactivity with monoclonal anti-human leucocyte antibody, designated 2D1. This 
      antibody detects a human leucocyte antigen (HLe-I) that is expressed strongly on 
      B and T lymphoid cells and weakly on early hemopoietic cells, but is not found on 
      normal mesenchymal and epithelial tissues. This study demonstrates the use of 
      this reagent in cryostat sections of tumor samples using indirect 
      immunofluorescence in combination with other lymphoid markers such as anti-T cell 
      serum, anti-Ia-like serum (detecting p28, 33 "B cell associated" membrane 
      antigen) and antisera to different immunoglobulin isotypes. Tumor cells from all 
      12 cases of epithelial malignancies and sarcomas were HLe-I- although adjacent 
      (normal) lymphoid cells showed strong positive staining. In contrast, 20 cases of 
      lymphoma (B- as well as T-cell types) were HLe-I+. Two other malignancies 
      involving the lymphoid system were HLe-I- and failed to express any of the other 
      lymphoid markers tested.
FAU - Pizzolo, G
AU  - Pizzolo G
FAU - Sloane, J
AU  - Sloane J
FAU - Beverley, P
AU  - Beverley P
FAU - Thomas, J A
AU  - Thomas JA
FAU - Bradstock, K F
AU  - Bradstock KF
FAU - Mattingly, S
AU  - Mattingly S
FAU - Janossy, G
AU  - Janossy G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Antilymphocyte Serum)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Antigen, B-Cell)
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - Antilymphocyte Serum
MH  - B-Lymphocytes/immunology
MH  - Clone Cells/immunology
MH  - Diagnosis, Differential
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Hybrid Cells/immunology
MH  - Immunoglobulin G/analysis
MH  - Lymphoma/*diagnosis
MH  - Male
MH  - Neoplasm Metastasis
MH  - Receptors, Antigen, B-Cell/immunology
MH  - T-Lymphocytes/immunology
EDAT- 1980/12/15 00:00
MHDA- 1980/12/15 00:01
CRDT- 1980/12/15 00:00
PHST- 1980/12/15 00:00 [pubmed]
PHST- 1980/12/15 00:01 [medline]
PHST- 1980/12/15 00:00 [entrez]
AID - 10.1002/1097-0142(19801215)46:12<2640::aid-cncr2820461218>3.0.co;2-s [doi]
PST - ppublish
SO  - Cancer. 1980 Dec 15;46(12):2640-7. doi: 
      10.1002/1097-0142(19801215)46:12<2640::aid-cncr2820461218>3.0.co;2-s.