PMID- 7007359
OWN - NLM
STAT- MEDLINE
DCOM- 19810421
LR  - 20190511
IS  - 0021-924X (Print)
IS  - 0021-924X (Linking)
VI  - 88
IP  - 5
DP  - 1980 Nov
TI  - Absence of albumin in tissues of analbuminemic rats.
PG  - 1413-7
AB  - Nagase analbuminemic rats (NAR) are deficient in serum albumin. Extravascular 
      regions of the tissues of NAR were tested for rat serum albumin by the 
      immunofluorescence staining technique. Albumin was not detectable in any of the 
      tissues of NAR tested (liver, kidney, muscle, skin, and small intestine), whereas 
      it was clearly demonstrated in all these tissues of normal rats. Furthermore, 
      extracts of NAR tissues, including the liver, contained no albumin detectable by 
      the single radial immunodiffusion method. These findings indicate that albumin is 
      not present in either the serum or extravascular regions of tissues of NAR, and 
      suggest that the deficiency of serum albumin in NAR is not due to impaired 
      albumin secretion from the liver or alteration of the tissue distribution of 
      albumin in certain tissues, but to the absence of its synthesis in the liver.
FAU - Sugiyama, K
AU  - Sugiyama K
FAU - Emori, T
AU  - Emori T
FAU - Nagase, S
AU  - Nagase S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Biochem
JT  - Journal of biochemistry
JID - 0376600
RN  - 0 (Albumins)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Albumins/*deficiency
MH  - Animals
MH  - Fluorescent Antibody Technique
MH  - Intestine, Small/analysis
MH  - Kidney/analysis
MH  - Liver/analysis
MH  - Male
MH  - Muscles/analysis
MH  - Mutation
MH  - Rats
MH  - Serum Albumin/deficiency
MH  - Skin/analysis
EDAT- 1980/11/01 00:00
MHDA- 1980/11/01 00:01
CRDT- 1980/11/01 00:00
PHST- 1980/11/01 00:00 [pubmed]
PHST- 1980/11/01 00:01 [medline]
PHST- 1980/11/01 00:00 [entrez]
AID - 10.1093/oxfordjournals.jbchem.a133110 [doi]
PST - ppublish
SO  - J Biochem. 1980 Nov;88(5):1413-7. doi: 10.1093/oxfordjournals.jbchem.a133110.