PMID- 7014208
OWN - NLM
STAT- MEDLINE
DCOM- 19810720
LR  - 20190829
IS  - 0013-7219 (Print)
IS  - 0013-7219 (Linking)
VI  - 27 Suppl 1
DP  - 1980 Dec
TI  - Clinical and hormonal aspects of the watery diarrhea-hypokalemia-achlorhydria 
      (WDHA) syndrome due to vasoactive intestinal polypeptide (VIP)-producing tumor.
PG  - 79-86
AB  - Three patients with the watery diarrhea-hypokalemia-achlorhydria (WDHA) syndrome 
      were studied. All had watery diarrhea, hypokalemia and hypercalcemia. Plasma 
      vasoactive intestinal polypeptide (VIP) levels determined by radioimmunoassay 
      were markedly elevated in these patients, indicating that they had VIP-producing 
      tumors. Plasma VIP levels determined serially after the operation indicate that 
      its determination is useful in estimating the effect of a treatment. As for 
      multiple endocrine neoplasia type 1 (MEN1), two out of the three cases belonged 
      to this category. Patient 1 had a brother with insulinoma, and in case 2, even 
      though there was no family history, the autopsy revealed not only multiple tumors 
      of the pancreas but also pituitary adenomas, chief cell hyperplasia of the 
      parathyroid glands, thyroid adenomas and adrenocortical adenomas. VIP and other 
      hormones in the tumors as well as in the plasma were examined extensively in 
      these cases. In case 1, VIP, gastrin and calcitonin were produced in the tumor 
      and only plasma VIP levels were elevated. In case 2, with multiple tumors, tumor 
      1 produced VIP, glucagon pancreatic polypeptide, gastrin and calcitonin, and 
      tumor 2, VIP, pancreatic polypeptide, gastrin and beta-melanocyte stimulating 
      hormone. In this case, plasma VIP, pancreatic polypeptide and glucagon levels 
      were elevated. In case 3, VIP and calcitonin were produced in the tumor, and 
      plasma VIP and calcitonin levels were elevated. These results indicate that (1) 
      VIP is a good tumor marker for the WDHA syndrome due to VIP-producing tumors; (2) 
      patients with the WDHA syndrome are sometimes associated with MEN1; and (3) 
      VIP-producing tumors are multiple hormone-producing tumors, and VIP predominantly 
      elevated in the plasma results in the WDHA syndrome, although other hormones such 
      as pancreatic polypeptide, glucagon and calcitonin are sometimes found to be 
      elevated in plasma without contributing to the clinical features.
FAU - Yamaguchi, K
AU  - Yamaguchi K
FAU - Abe, K
AU  - Abe K
FAU - Adachi, I
AU  - Adachi I
FAU - Tanaka, M
AU  - Tanaka M
FAU - Ueda, M
AU  - Ueda M
FAU - Oka, Y
AU  - Oka Y
FAU - Miyakawa, S
AU  - Miyakawa S
FAU - Kameya, T
AU  - Kameya T
FAU - Yanaihara, N
AU  - Yanaihara N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Endocrinol Jpn
JT  - Endocrinologia japonica
JID - 0376546
RN  - 0 (Gastrins)
RN  - 0 (Gastrointestinal Hormones)
RN  - 0 (Insulin)
RN  - 0 (Parathyroid Hormone)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 9007-12-9 (Calcitonin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Achlorhydria/*physiopathology
MH  - Adult
MH  - Calcitonin/blood
MH  - Diarrhea/*physiopathology
MH  - Female
MH  - Gastrins/blood
MH  - Gastrointestinal Hormones/*blood
MH  - Glucagon/blood
MH  - Humans
MH  - Hypokalemia/*physiopathology
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/diagnosis/*metabolism
MH  - Parathyroid Hormone/blood
MH  - Syndrome
MH  - Vasoactive Intestinal Peptide/*blood
EDAT- 1980/12/01 00:00
MHDA- 1980/12/01 00:01
CRDT- 1980/12/01 00:00
PHST- 1980/12/01 00:00 [pubmed]
PHST- 1980/12/01 00:01 [medline]
PHST- 1980/12/01 00:00 [entrez]
AID - 10.1507/endocrj1954.27.supplement_79 [doi]
PST - ppublish
SO  - Endocrinol Jpn. 1980 Dec;27 Suppl 1:79-86. doi: 
      10.1507/endocrj1954.27.supplement_79.