PMID- 7015852
OWN - NLM
STAT- MEDLINE
DCOM- 19810723
LR  - 20190627
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 70
IP  - 5
DP  - 1981 May
TI  - Immunoglobulin E (IgE) multiple myeloma: a case report and review of the 
      literature.
PG  - 1127-32
AB  - A case of immunoglobulin E (IgE) myeloma with clinical features of "classic" 
      myeloma is presented. Skeletal roentgenograms showed osteoporosis and compression 
      fractures of the vertebrae but no osteosclerosis. Protein analyses revealed an M 
      component of the IgE kappa type with a concentration of 3.1 g/dl. Although 
      morphologic examination revealed that the plasma cells were not so 
      differentiated, well-developed Golgi apparatus and abundant rough-surfaced 
      endoplasmic reticulum were observed. An indirect immunofluorescence technique 
      showed characteristic apple green fluorescence. The E myeloma protein of our 
      patient had no antibody activity. Treatment with melphalan or cyclophosphamide 
      resulted in a decrease in the serum IgE level and in the level of Bence Jones 
      protein in the urine. The clinical and laboratory features of IgE myeloma were 
      summarized and compared with those of other classes of myeloma.
FAU - Endo, T
AU  - Endo T
FAU - Okumura, H
AU  - Okumura H
FAU - Kikuchi, K
AU  - Kikuchi K
FAU - Munakata, J
AU  - Munakata J
FAU - Otake, M
AU  - Otake M
FAU - Nomura, T
AU  - Nomura T
FAU - Asakawa, H
AU  - Asakawa H
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Myeloma Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - 9006-99-9 (Bence Jones Protein)
RN  - Q41OR9510P (Melphalan)
SB  - IM
MH  - Aged
MH  - Bence Jones Protein/urine
MH  - Cyclophosphamide/therapeutic use
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Melphalan/therapeutic use
MH  - Middle Aged
MH  - Multiple Myeloma/diagnostic imaging/*immunology/ultrastructure
MH  - Myeloma Proteins/*analysis
MH  - Plasma Cells/ultrastructure
MH  - Radiography
RF  - 29
EDAT- 1981/05/01 00:00
MHDA- 1981/05/01 00:01
CRDT- 1981/05/01 00:00
PHST- 1981/05/01 00:00 [pubmed]
PHST- 1981/05/01 00:01 [medline]
PHST- 1981/05/01 00:00 [entrez]
AID - 0002-9343(81)90887-1 [pii]
AID - 10.1016/0002-9343(81)90887-1 [doi]
PST - ppublish
SO  - Am J Med. 1981 May;70(5):1127-32. doi: 10.1016/0002-9343(81)90887-1.