PMID- 7031111
OWN - NLM
STAT- MEDLINE
DCOM- 19820212
LR  - 20190723
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 68
IP  - 6
DP  - 1981 Dec
TI  - Effect of erythromycin on theophylline kinetics.
PG  - 427-31
AB  - The effect of erythromycin base on theophylline kinetics was studied in eight 
      informed, nonsmoking, adult males who received a 15-min infusion of theophylline 
      (aminophylline) 5 mg/kg, prior to (control) and after (experimental) a 7-day 
      course of 1 gm daily erythromycin base (E-Mycin). Each subject acted as his own 
      control. Multiple serum samples were collected for 24 hr after each dose and were 
      analyzed for theophylline by high-pressure liquid chromatography. The mean +/- SD 
      pharmacokinetic parameters for each phase of study were as follows: apparent 
      volume of distribution (L/kg) 0.45 +/- 0.05 (control), 0.41 +/- 0.05 
      (experimental); clearance (ml . min/kg) 0.83 +/- 0.17 (control), 0.60 +/- 0.11 
      (experimental); elimination half-life (hr) 6.65 +/- 1.88 (control), 8.10 +/- 1.58 
      (experimental). Erythromycin significantly affected the elimination half-life and 
      clearance of theophylline (p less than 0.05). The apparent volume of distribution 
      was unaffected (p greater than 0.05). Therefore patients being administered 
      theophylline appear to be at added risk for the development of toxicity when 
      erythromycin is added to the therapeutic regimen.
FAU - Prince, R A
AU  - Prince RA
FAU - Wing, D S
AU  - Wing DS
FAU - Weinberger, M M
AU  - Weinberger MM
FAU - Hendeles, L S
AU  - Hendeles LS
FAU - Riegelman, S
AU  - Riegelman S
LA  - eng
GR  - AI 16151-01/AI/NIAID NIH HHS/United States
GR  - RR59/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 63937KV33D (Erythromycin)
RN  - C137DTR5RG (Theophylline)
SB  - IM
MH  - Adult
MH  - Clinical Trials as Topic
MH  - Drug Interactions
MH  - Erythromycin/blood/*pharmacology
MH  - Half-Life
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Theophylline/adverse effects/blood/*metabolism
MH  - Urine/analysis
EDAT- 1981/12/01 00:00
MHDA- 1981/12/01 00:01
CRDT- 1981/12/01 00:00
PHST- 1981/12/01 00:00 [pubmed]
PHST- 1981/12/01 00:01 [medline]
PHST- 1981/12/01 00:00 [entrez]
AID - 0091-6749(81)90196-2 [pii]
AID - 10.1016/0091-6749(81)90196-2 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 1981 Dec;68(6):427-31. doi: 10.1016/0091-6749(81)90196-2.