PMID- 7035056
OWN - NLM
STAT- MEDLINE
DCOM- 19820412
LR  - 20190821
IS  - 0143-5221 (Print)
IS  - 0143-5221 (Linking)
VI  - 62
IP  - 1
DP  - 1982 Jan
TI  - Fibrin deposition in the kidney and renal blood flow during intravascular 
      coagulation in the rat: influence of the renin-angiotensin system.
PG  - 35-41
AB  - 1. Intravascular coagulation in the kidneys of rats was induced by intravenous 
      infusion of thrombin and by inhibition of fibrinolysis with tranexamic acid under 
      alpha-chloralose anaesthesia. The amount of fibrin in the kidneys was measured 
      with radioactively labelled fibrinogen. Chronic saline loading and inhibition of 
      angiotension II (ANG II) with saralasin reduced the fibrin deposition in the 
      kidneys. Infusion of ANG II had the opposite effect. 2. Renal and aortic blood 
      flows were measured by injection of radioactively labelled microspheres. After 
      thrombin infusion the renal and aortic blood flows were reduced to about 
      one-third of the pre-infusion values. Chronic saline loading diminished these 
      changes, but saralasin had no effect. 3. Plasma renin activity (PRA), measured by 
      radioimmunoassay, decreased by about 50% after thrombin infusion. 4. The 
      reduction in PRA and the lack of effect of saralasin indicate that the 
      renin-angiotensin system is not the mediator of the observed decrease in the 
      renal blood flow. As saralasin reduced the amount of fibrin the mechanism 
      regulating fibrin deposition appears to be independent of the mechanism that 
      reduces the renal blood flow.
FAU - Stahl, E
AU  - Stahl E
FAU - Karlberg, B E
AU  - Karlberg BE
FAU - Rammer, L
AU  - Rammer L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 11128-99-7 (Angiotensin II)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 9001-31-4 (Fibrin)
RN  - EC 3.4.23.15 (Renin)
RN  - H2AFV2HE66 (Saralasin)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Aorta/physiology
MH  - Blood Flow Velocity
MH  - Disseminated Intravascular Coagulation/*physiopathology
MH  - Female
MH  - Fibrin/*metabolism
MH  - Kidney/drug effects/*metabolism
MH  - Lung/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Renal Circulation/drug effects
MH  - Renin/blood
MH  - *Renin-Angiotensin System
MH  - Saralasin/pharmacology
MH  - Sodium Chloride/metabolism
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
AID - 10.1042/cs0620035 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 1982 Jan;62(1):35-41. doi: 10.1042/cs0620035.