PMID- 7039321
OWN - NLM
STAT- MEDLINE
DCOM- 19820527
LR  - 20190615
IS  - 0002-9378 (Print)
IS  - 0002-9378 (Linking)
VI  - 142
IP  - 7
DP  - 1982 Apr 1
TI  - Prostacyclin production during pregnancy: comparison of production during normal 
      pregnancy and pregnancy complicated by hypertension.
PG  - 817-22
AB  - We investigated prostacyclin (PGI2) biosynthesis during pregnancy by measuring 
      urinary excretion of 2,3-dinor-6-keto-prostaglandin F1 alpha (dinor) and 
      15-keto-13,14-dihydro-2,3-dinor-6-keto-prostaglandin F1 alpha (15 kd dinor) with 
      the use of specific gas chromatography-mass spectrometry assays. Nine 
      normotensive nonpregnant women, five normotensive women in the mid-trimester of 
      pregnancy, eight normotensive women in the third trimester of pregnancy, and six 
      women who developed hypertension during the third trimester provided 24-hour 
      samples of urine. Normal pregnant women had a fivefold increase in urinary 
      excretion of dinor in comparison to nonpregnant women (253 +/- 21 ng dinor/gm 
      creatinine for controls vs. 1,224 +/- 110 and 1,127 +/- 152 for second and third 
      trimesters) (mean +/- SEM). Pregnant subjects with hypertension had a significant 
      (50%) reduction in urinary dinor excretion in comparison to normotensive pregnant 
      subjects (561 +/- 105 ng dinor/gm creatinine). In subjects selected from each 
      group, the ratio of dinor to 15 kd dinor remained constant. We conclude that PGI2 
      biosynthesis is increased during normal pregnancy, and that this increase is less 
      in pregnancy-induced hypertension. This raises the possibility that PGI2 helps 
      mediate hemodynamic changes during normal pregnancy, and that a relative decrease 
      in production might be related to the pathogenesis of pregnancy-induced 
      hypertension.
FAU - Goodman, R P
AU  - Goodman RP
FAU - Killam, A P
AU  - Killam AP
FAU - Brash, A R
AU  - Brash AR
FAU - Branch, R A
AU  - Branch RA
LA  - eng
GR  - GM07569/GM/NIGMS NIH HHS/United States
GR  - HD05797/HD/NICHD NIH HHS/United States
GR  - HL14192/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
RN  - 0 (Prostaglandins)
RN  - 0 (Prostaglandins A, Synthetic)
RN  - AYI8EX34EU (Creatinine)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Adult
MH  - Creatinine/urine
MH  - Epoprostenol/*biosynthesis
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Hypertension/*etiology/urine
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*etiology/urine
MH  - Pregnancy Trimester, Second
MH  - Pregnancy Trimester, Third
MH  - Prostaglandins/*biosynthesis
MH  - Prostaglandins A, Synthetic/urine
EDAT- 1982/04/01 00:00
MHDA- 1982/04/01 00:01
CRDT- 1982/04/01 00:00
PHST- 1982/04/01 00:00 [pubmed]
PHST- 1982/04/01 00:01 [medline]
PHST- 1982/04/01 00:00 [entrez]
AID - S0002-9378(16)32525-X [pii]
AID - 10.1016/s0002-9378(16)32525-x [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 1982 Apr 1;142(7):817-22. doi: 
      10.1016/s0002-9378(16)32525-x.