PMID- 7048086
OWN - NLM
STAT- MEDLINE
DCOM- 19820910
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 94
IP  - 1
DP  - 1982 May
TI  - Photodynamic effects of dyes on bacteria. V. Mutagenesis by acridine orange and 
      460-nm or 500-nm light in strains of Escherichia coli that differ in repair 
      capability.
PG  - 39-51
AB  - With acridine orange (AO) and monochromatic 460-nm light, the mutation rate of 
      the wild-type strain of Escherichia coli (WP2) was 3-fold higher than that of the 
      endonuclease-deficient strain WP2 (uvrA). In addition, the mutation rates of the 
      recombination-deficient strains WP10 (recA) and Bs-1 (uvrB lexA) were also about 
      3-fold less than that of wild-type strain. This observation is in striking 
      contrast to the earlier results with AO and 500-nm light in which strains WP10 
      and Bs-1 yielded mutation rates that were 12-fold and 5-fold greater, 
      respectively, than the wild-type response. The relatively large decrease in 
      mutation rate when the uvrA endonuclease was absent together with structural 
      considerations in the binding of AO to DNA lead us to propose that the major 
      lesions leading to mutations produced by 460-nm light in the presence of AO may 
      be true DNa single-strand breaks and occur before DNA replication.
FAU - Hass, B S
AU  - Hass BS
FAU - Webb, R B
AU  - Webb RB
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Coloring Agents)
RN  - 0 (DNA, Bacterial)
RN  - 0 (Mutagens)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*pharmacology
MH  - Coloring Agents/*pharmacology
MH  - DNA Repair
MH  - DNA, Bacterial/genetics
MH  - Escherichia coli/*drug effects/genetics/radiation effects
MH  - Light
MH  - Mutagens/*pharmacology
MH  - Photochemistry
EDAT- 1982/05/01 00:00
MHDA- 1982/05/01 00:01
CRDT- 1982/05/01 00:00
PHST- 1982/05/01 00:00 [pubmed]
PHST- 1982/05/01 00:01 [medline]
PHST- 1982/05/01 00:00 [entrez]
AID - 0027-5107(82)90167-1 [pii]
AID - 10.1016/0027-5107(82)90167-1 [doi]
PST - ppublish
SO  - Mutat Res. 1982 May;94(1):39-51. doi: 10.1016/0027-5107(82)90167-1.