PMID- 7050060
OWN - NLM
STAT- MEDLINE
DCOM- 19821012
LR  - 20171213
IS  - 0161-7567 (Print)
IS  - 0161-7567 (Linking)
VI  - 52
IP  - 6
DP  - 1982 Jun
TI  - Effects of streptozotocin diabetes, insulin treatment, and training on the 
      diaphragm.
PG  - 1471-5
AB  - The adaptive capability of the diaphragm, the only skeletal muscle considered a 
      vital organ, has received little investigative attention compared with the limb 
      muscles. Since it is chronically active, we asked whether it will adapt to 
      exercise training and if so to what extent. Metabolic adaptations of the 
      diaphragm to exercise training were studied under three conditions: normal, 
      streptozotocin-diabetic, and diabetic receiving insulin treatment. The activities 
      of hexokinase (HK), phosphorylase, and phosphofructokinase (PFK) in the diaphragm 
      of sedentary diabetic Sprague-Dawley albino rats were 22-36% lower than in normal 
      animals. Insulin treatment returned PFK and HK to normal and above normal, 
      respectively. Tricarboxylic acid cycle marker enzymes were not affected by the 
      diabetic condition or insulin treatment. beta-Oxidation enzyme 3-hydroxyacyl-CoA 
      dehydrogenase (HADH) was 60% higher than normal in the diabetic diaphragm and 
      returned to normal with insulin treatment. Training resulted in increases in the 
      glycolytic and aerobic capacities of all groups. The aerobic changes were similar 
      to those of limb muscles. HADH activity was increased in the normal and diabetic 
      insulin-treated trained groups, but because of its already high activity in the 
      diabetic diaphragm, it did not require an adaptation.
FAU - Ianuzzo, C D
AU  - Ianuzzo CD
FAU - Noble, E G
AU  - Noble EG
FAU - Hamilton, N
AU  - Hamilton N
FAU - Dabrowski, B
AU  - Dabrowski B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol Respir Environ Exerc Physiol
JT  - Journal of applied physiology: respiratory, environmental and exercise physiology
JID - 7801242
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 9005-79-2 (Glycogen)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Experimental/drug therapy/*physiopathology
MH  - Diaphragm/enzymology/metabolism/physiology/*physiopathology
MH  - Glycogen/metabolism
MH  - Insulin/*therapeutic use
MH  - Male
MH  - *Physical Education and Training
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1982/06/01 00:00
MHDA- 1982/06/01 00:01
CRDT- 1982/06/01 00:00
PHST- 1982/06/01 00:00 [pubmed]
PHST- 1982/06/01 00:01 [medline]
PHST- 1982/06/01 00:00 [entrez]
AID - 10.1152/jappl.1982.52.6.1471 [doi]
PST - ppublish
SO  - J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun;52(6):1471-5. doi: 
      10.1152/jappl.1982.52.6.1471.