PMID- 7059484
OWN - NLM
STAT- MEDLINE
DCOM- 19820527
LR  - 20131121
IS  - 0007-0971 (Print)
IS  - 0007-0971 (Linking)
VI  - 76
IP  - 1
DP  - 1982 Jan
TI  - Acute severe asthma treated without steroids.
PG  - 15-9
AB  - Sixty patients with acute severe asthma were treated by conventional methods in 
      all respects except for the use of steroids. Patients who were not currently 
      taking systemic steroids (30) received none during the severe attack, and those 
      who were currently taking systemic steroids (30) were given 400 mg hydrocortisone 
      daily. The results were compared to a further group of 30 patients with acute 
      severe asthma of similar severity who were treated in the same hospital by the 
      same methods but with much larger doses of hydrocortisone (1200 mg daily). All 60 
      patients recovered and the time course, changes in heart rate and peak expiratory 
      flow (PEFR) were similar in all groups. These results suggest that steroids are 
      of doubtful value in the treatment of acute severe asthma and further randomized 
      and controlled trials are required.
FAU - Luksza, A R
AU  - Luksza AR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Dis Chest
JT  - British journal of diseases of the chest
JID - 7511123
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Asthma/*drug therapy/physiopathology
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Hydrocortisone/administration & dosage/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Peak Expiratory Flow Rate
EDAT- 1982/01/01 00:00
MHDA- 1982/01/01 00:01
CRDT- 1982/01/01 00:00
PHST- 1982/01/01 00:00 [pubmed]
PHST- 1982/01/01 00:01 [medline]
PHST- 1982/01/01 00:00 [entrez]
PST - ppublish
SO  - Br J Dis Chest. 1982 Jan;76(1):15-9.