PMID- 7062246
OWN - NLM
STAT- MEDLINE
DCOM- 19820512
LR  - 20190711
IS  - 0022-3549 (Print)
IS  - 0022-3549 (Linking)
VI  - 71
IP  - 2
DP  - 1982 Feb
TI  - Solubility in binary solvent systems I: Specific versus nonspecific interactions.
PG  - 201-5
AB  - Solubilities are reported for benzil in carbon tetrachloride-alkane (isooctane, 
      n-octane, cyclooctane) systems at 25 degrees and in similar binary mixtures 
      containing cyclohexane plus alkane. The results of these measurements are 
      compared to solution models previously developed for solubility in systems 
      containing specific solute-solvent interactions and to models for purely 
      nonspecific interactions. A stoichiometric complexation model based primarily on 
      specific solute-solvent interactions requires several equilibrium constants to 
      mathematically describe the experimental solubilities in binary carbon 
      tetrachloride mixtures. However, there was no direct experimental evidence to 
      suggest complexation between benzil and carbon tetrachloride. In comparison, 
      expressions derived from the Nearly Ideal Binary Solvent (NIBS) model for 
      nonspecific interactions predict experimental solubilities with a maximum 
      deviation of 5% and an overall deviation of 1.0%. The success of the NIBS 
      approach for this system is significant because the mole fraction solubility of 
      benzil changes by a factor of 14 in the carbon tetrachloride-isooctane system.
FAU - Acree, W E Jr
AU  - Acree WE Jr
FAU - Rytting, J H
AU  - Rytting JH
LA  - eng
GR  - GM22357/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Alkanes)
RN  - 0 (Solvents)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - N45G3015PA (Phenylglyoxal)
RN  - S85X61172J (benzil)
SB  - IM
MH  - Alkanes
MH  - Carbon Tetrachloride
MH  - *Chemistry, Pharmaceutical
MH  - Models, Chemical
MH  - Phenylglyoxal/analogs & derivatives
MH  - *Solubility
MH  - Solvents
EDAT- 1982/02/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1982/02/01 00:00
PHST- 1982/02/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1982/02/01 00:00 [entrez]
AID - S0022-3549(15)44030-4 [pii]
AID - 10.1002/jps.2600710216 [doi]
PST - ppublish
SO  - J Pharm Sci. 1982 Feb;71(2):201-5. doi: 10.1002/jps.2600710216.