PMID- 7065271
OWN - NLM
STAT- MEDLINE
DCOM- 19820527
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 242
IP  - 4
DP  - 1982 Apr
TI  - Differential effects of histamine on protein permeability in dog lung and 
      forelimb.
PG  - H565-72
AB  - In this study, the effects of histamine on the microvascular permeability of a 
      canine, isolated perfused left lower lung lobe (LLL) and a forelimb preparation 
      were evaluated by comparing the apparent filtered volumes (VF) calculated from 
      the increases in hematocrit (Hct) and plasma protein concentration (Pr) observed 
      during filtration. In the LLL and forelimb, the elevation of venous pressure (Pv) 
      to 15.5 Torr resulted in a ratio of filtered volumes (VF,Pr/VF,Hct) of 0.97 and 
      0.99, respectively. In the LLL, histamine administration did not significantly 
      change this ratio, whereas the addition of methylene blue decreased it to 0.62. 
      In the forelimb, histamine transiently decreased VF,Pr/VF,Hct to 0.23. After 
      recovery, the elevation of Pv to cause further filtration resulted in a ratio of 
      0.94. These data suggest that intrinsic differences in the regulation of 
      microvascular permeability exist between blood vessels of the lung and forelimb, 
      in that a histamine dose that significantly increased the protein permeability of 
      the forelimb had no measurable effect on the LLL.
FAU - Maron, M B
AU  - Maron MB
LA  - eng
GR  - 5SO8RR-09026/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Proteins)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Blood Proteins/*metabolism
MH  - Blood Volume
MH  - Dogs
MH  - Forelimb/blood supply
MH  - Hematocrit
MH  - Histamine/*pharmacology
MH  - Lung/*blood supply
MH  - Microcirculation/*drug effects
MH  - Muscles/*blood supply
MH  - Permeability
MH  - Pulmonary Circulation/*drug effects
EDAT- 1982/04/01 00:00
MHDA- 1982/04/01 00:01
CRDT- 1982/04/01 00:00
PHST- 1982/04/01 00:00 [pubmed]
PHST- 1982/04/01 00:01 [medline]
PHST- 1982/04/01 00:00 [entrez]
AID - 10.1152/ajpheart.1982.242.4.H565 [doi]
PST - ppublish
SO  - Am J Physiol. 1982 Apr;242(4):H565-72. doi: 10.1152/ajpheart.1982.242.4.H565.